The invention discloses an operation control method, device, storage medium and multi-connection system. The method includes: acquiring the outdoor ambient temperature, target temperature and indoor ambient temperature of the multi-connection system; the multi-connection system is a cascading circulation system, including: The first temperature-level circulation system and the second temperature-level circulation system; determine the operating conditions of the multi-connected system according to the outdoor ambient temperature, including: the first set working condition, the second set working condition and / or the third set working condition Under the determined operating conditions, the operating mode of the multi-line system is determined according to the target temperature, including: the first setting mode, the second setting mode, the third setting mode, the fourth setting mode, and / or The fifth setting mode: in the determined operation mode, the operation process of the multi-connected system is controlled according to the indoor ambient temperature. This solution can solve the problem of not being able to meet the comfort needs of users in different environments, and achieve the effect of meeting the comfort needs of users in different environments.