The invention provides a midsole adhesive with high solid content and a preparation method thereof. The midsole adhesive with high solid content is prepared from the following raw materials in parts by weight: SBS elastomer: 15-20 parts, methylcyclohexane: 50-60 parts, butanone: 10-15 parts, methyl Methyl acrylate: 10~15 parts, vinyl acetate: 2~5 parts, acrylic acid: 1~2 parts, initiator: 0.2~0.3 parts, terminator: 0.5~1 parts, terpene resin: 10~15 parts, C9 Petroleum resin: 5~10 parts, 138 glycerin resin: 5~10 parts, rosin: 20~30 parts. The midsole adhesive prepared by the invention has high solid content, low VOC content, clear glue solution, good stability, long stickiness maintenance time, low cost, wide source of raw materials, and good application prospect.