The invention discloses a solid welding wire surface degreasing and rust removing mixed cleaning agent, a manufacturing method and a use method thereof, wherein per L of the mixed cleaning agent comprises: 120-180 g of sulfuric acid, 15-20 g of peregal, 0.03-0.07 g of sodium lauryl sulfate, 1-10 g of citric acid, 0.5-2.0 g of thiourea, and the balance of water. The manufacturing method comprises:preparing sulfuric acid with a mass percent concentration of 98%; weighing the sulfuric acid according to the ratio of 120-180 g of the sulfuric acid in per liter of the mixed cleaning agent; and sequentially adding peregal, sodium lauryl sulfate, citric acid, thiourea and water to the sulfuric acid. The use method comprises: pouring the mixed cleaning agent into a cleaning groove, heating the mixed cleaning agent in the cleaning groove to a temperature of 40 DEG C, and cleaning at a single welding wire electrolysis tic current of 18 A after a to-be-cleaned solid welding wire penetrates through the mixed cleaning agent. A purpose of the present invention is to solve the problems of environment pollution caused by acids and alkalis, high treatment cost, multiple process control points, large cross-effects, large fluctuations in cleaning quality, and the like in the prior art.