The invention relates to a brewing process of beer with watermelon juice. The brewing process comprises the following steps: 1) weighing soybean cake powder and peanut cake powder which are free of mildew and crushed, uniformly mixing the soybean cake powder and peanut cake powder with crushed barley malts to form a mixture I, then, preparing malt juice by saccharifying, filtering, boiling, circulating and precipitating, and cooling, and pumping the malt juice into a sterile fermentation tank; 2) quickly pumping watermelon juice into the fermentation tank, mixing with the malt juice, then, adding honey which accounts for 1.0-1.5wt% of the watermelon juice; 3) inoculating activated beer dry yeast to ferment, and introducing oxygen gas to enable the oxygen content to reach 11-13mg/L, and measuring sugar degree once every 24 hours; 4) after the fermentation is ended, filtering by use of a diatomite filter to obtain the beer with watermelon juice. According to the brewing process of the beer with the watermelon juice disclosed by the invention, the watermelon juice is taken as the main material, the barely malts, the soybean cake powder, the peanut cake powder, the honey, and the like are taken as auxiliary materials, so that the flavor substances in the watermelon are kept as much as possible in a low-temperature fermentation process, and therefore, the variety of the summer draught beer is enriched.