53 results about "Fatty Depositions" patented technology

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

This invention relates to the field of biomedical technology, specifically to the application of 6-ketolithocholic acid in the preparation of drugs that reduce fat deposition. The 6-ketolithocholic acid in this invention inhibits the accumulation of lipid droplets in adipocytes and suppresses gene expression in the PPARγ pathway involved in lipid synthesis, thereby achieving the function of reducing fat deposition. The structural formula of the 6-ketolithocholic acid is: [Insert structural formula here].

The invention provides an organoid culture medium, an organoid culture method and application of the organoid culture medium, the organoid culture medium comprises a first-stage culture medium, the first-stage culture medium comprises a first-stage basic culture medium and first-stage addition factors, and the first-stage addition factors comprise N-acetylcysteine, nicotinamide, a ROCK inhibitor, Noggin, R-spondin, EGF, HGF, Gastrin, FGF10, Blebbistatin, Forskolin, A83-01, LDN193189, DAPT, TGF-alpha and UDAC. By using the organoid culture medium, the liver organoid and the fatty liver organoid can be effectively obtained, and the obtained fatty liver organoid has obvious fat deposition, is sensitive to fatty liver treatment drugs, highly restores the physiological status when human body fatty liver diseases occur, and has high application value.

The application belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to a fermented Lactobacillus muci genus with a function of delaying aging and application thereof. The bacterium was preserved in the Guangdong Microbial Culture Collection Center on August 27, 2025, and the preservation number is GDMCC No: 66877. Experimental results show that the bacterium has excellent antioxidant performance, can relieve oxidative damage, delay aging, inhibit the expression of aging-related genes, and has the ability to improve the memory reproduction ability decline caused by aging, improve the body's anti-inflammatory ability, improve the intestinal flora imbalance induced by aging, and can regulate the level of fat factors, improve energy metabolism, and has the potential of anti-fat deposition and protection of liver function. Therefore, the bacterium can be used to develop products with multiple beneficial functions such as delaying aging, helping to antioxidant, auxiliary improving memory, helping to regulate intestinal flora, and has the advantages of high safety, strong gastrointestinal tolerance, good colonization ability, and has good application value.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

This invention discloses anti-leptin monoclonal antibodies and their applications, relating to the field of biotechnology. This invention develops anti-leptin monoclonal antibodies 2A122H7 and 6B62E3, which can effectively recognize leptin. The ELISA kits prepared using these monoclonal antibodies 2A122H7 and 6B62E3 include indirect ELISA and double-antibody sandwich ELISA kits, exhibiting high specificity and sensitivity for the tested samples, and are convenient, efficient, and cost-effective. This invention provides effective technical support for advancing research on the regulatory mechanisms of economic traits such as feed intake, fat deposition, and reproduction in poultry.

The application provides a molecular marker related to tail fat deposition of sheep, a detection method and application thereof. Through PCR amplification and sequence analysis of rBAT (SLC3A1) gene of the sheep, a C / T polymorphic site at the 689th position of the amplified fragment is found, further, the polymorphic site of 1286 Hu sheep is detected by using KASPar primers, a least square model is established, and correlation analysis of the genotypes and growth traits is carried out, and finally it is determined that the amplified RBAT gene fragment can be used as a molecular marker related to tail fat of the sheep. The application can be used for selecting and reserving TT homozygous sheep into a core group, for reducing tail fat deposition of the sheep, and for increasing economic benefits.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

This invention provides the application of a *Breago brevis* strain in the preparation of products that promote intramuscular fat deposition in livestock and poultry. The *Breago brevis* strain is *Breago brevis* JCM 32280. Under high-fiber dietary conditions, supplementation with *Breago brevis* JCM 32280 of this invention can efficiently degrade fiber to produce high concentrations of butyrate. Butyrate, as a key effector molecule, can directly bind to and activate PPARγ receptors in host cells, thereby upregulating the MOGAT2-mediated triglyceride synthesis pathway, significantly increasing body fat percentage in mammals and promoting intramuscular fat (marbling). Simultaneously, this strain can reshape the intestinal microecology, specifically increasing the abundance of beneficial intestinal lactobacilli and enhancing the intestinal mucus barrier, providing a safe and efficient microbial preparation strategy for improving the fat deposition capacity and meat flavor of livestock and poultry.

The invention relates to the technical field of poultry health assessment, in particular to a method for predicting and identifying the high fat deposition risk of the liver of a laying hen based on blood amino acid parameters. The method comprises the following steps: collecting a blood sample when the laying hen is in a metabolic state after absorption, detecting the total amino acid content and the alanine content in blood, and substituting blood parameters into a pre-established liver triglyceride prediction model to obtain the predicted liver triglyceride content, and comparing the prediction results to judge the high fat deposition risk of the liver of the laying hen. According to the method, the laying hens do not need to be slaughtered and sampled, the fat deposition state of the livers of the living laying hens can be rapidly evaluated, and the method is suitable for early screening and risk early warning of high fat deposition of the livers of the laying hens under the large-scale breeding condition.

The invention discloses application of an Fn1-PPARbeta / delta signal channel related to a cardiac liver disease. The cardiac liver disease model is constructed according to the conditions that the liver development of young individuals is delayed due to heart injury and both adult and young individuals have serious fatty livers. In the model, the Fn1 protein level in the heart and blood is obviously increased compared with the normal level. Based on a zebra fish heart ablation means, after heart ablation injury, the heart specific knock-down Fn1 can lead to reduction of the Fn1 protein level in blood and alleviation of liver development retardation and fat deposition. Through the screening of transcriptomics, the PPARbeta / delta protein in the liver is found to be a potential downstream effect factor of Fn1. The liver specific overexpression PPARbeta / delta protein can significantly relieve abnormal phenotypes such as liver fat deposition caused by heart injury, and after the liver specific knock-down PPARbeta / delta protein, the protection effect of knock-down Fn1 on the liver disappears under the condition of heart injury. Therefore, the Fn1 protein and the PPARbeta / delta protein can be used as targets for preventing and treating the cardiac liver injury, and are used for preparing medicines for improving the cardiac liver injury, so that a new way is provided for treating the cardiac liver disease.

The invention belongs to the technical field of molecular genetics, and particularly relates to an SNP (Single Nucleotide Polymorphism) marker related to identification of sheep tail fat deposition and application of the SNP marker, and the SNP molecular marker is located at the 4146459th nucleotide site C / A mutation on the No.15 chromosome of AR-UIRamv3.0 reference genome (GCF016772045.2). The technology has the advantages of high accuracy, high detection speed, low cost, easiness in result judgment and the like. The SNP locus detection is used for carrying out thin tail type sheep early selection, shortening the breeding period and accelerating the breeding process, an fat tail type sheep early selection technology is established, the breeding time of fat tail type sheep with excellent characters is shortened, the breeding cost is reduced, and the application value is very high.

The invention belongs to the technical field of molecular biology, and relates to miRNA for regulating and controlling the content of fat and / or unsaturated fatty acid in buffalo muscle and application of the miRNA. The miRNA is miR-30f (bta-miR-30f), and the fat deposition in the buffalo muscle and the composition of unsaturated fatty acid are influenced by regulating and controlling the expression of an RAD23B gene. The invention finds that transfection of a bta-miR-30f simulant in buffalo intramuscular fat cells can significantly improve intramuscular fat content and unsaturated fatty acid proportion, while transfection of an inhibitor shows a reverse effect. Further research finds that knock-down of the RAD23B gene can also increase the content of triglyceride and unsaturated fatty acid in buffalo muscle tissue. Important gene resources and molecular breeding technical means are provided for genetic improvement of buffalo meat quality characters (including flavor characteristics and nutritional value).

Systems and methods for treating cellulite, including apparatus applying or methods involving separating a membrane to eliminate or reduce cellulite appearance. In one method, an interventional tool is placed between tissue layers to act and treat septums connecting the tissue layers containing fat deposits therebetween.

The application discloses a hypoglycemic and hypolipidemic composition from the leaves of pandamus, a preparation method and application thereof. The composition contains p-coumaric acid, rutin, kaempferol-3-O-rutinoside, pandamarilactonine-A, pandamarilactone-1 and pandamarilactone-2. The composition with a preferred mass ratio has a certain synergistic effect. Under the premise of a consistent total dose, the composition is superior to p-coumaric acid, rutin and kaempferol-3-O-rutinoside in improving insulin resistance and reducing fat deposition, and is also superior to a pandamus alkaloid composition composed of pandamarilactonine-A, pandamarilactone-1 and pandamarilactone-2, which indicates that there is a synergistic effect among the components of the composition.

The application relates to a mutant type of an INSIG1 gene for regulating fat deposition of animals and application thereof, wherein the mutation is located at the 3725th base of a nucleotide sequence shown in SEQ ID NO. 1, and is an A>G single nucleotide mutation. The application analyzes the genetic basis of fat deposition of animals by using comparative genomics, finds that a strictly conserved site of an INSIG1 gene corresponds to parallel replacement of histidine to arginine of amino acids, and the potential function of the strictly conserved site in fat deposition and mobilization is prompted.

The invention belongs to the technical field of nutritional compositions and biological medicines, and particularly relates to a composition with a liver protection effect as well as a preparation method, application and a product thereof. The composition disclosed by the invention is prepared from Akkermania muciniphila and a globe artichoke extract, wherein the weight ratio of the Akkermania muciniphila to the globe artichoke extract is (1 to 8) to (1.6 to 10). The composition disclosed by the invention has a protection effect on various liver injuries such as alcoholic liver injury, chemical liver injury and non-alcoholic fatty liver injury, is obviously superior to a single bacterial preparation, a single globe artichoke extract and an existing conventional liver protection product, and can effectively reduce the levels of ALT and AST in serum, reduce liver fat deposition, inhibit liver inflammatory response and realize a liver protection effect.

This invention relates to the fields of gene editing and animal genetic breeding technology, and discloses a precise editing method for key genes regulating lipid metabolism in cattle and sheep. The method includes: constructing a comprehensive lipid metabolism network map integrating transcriptomic, proteomic, and metabolomic data; using a graph neural network to identify key node genes with high flow weights and their negative feedback pathways; simulating cascade reactions after gene perturbation to assess compensatory effects; screening for multi-gene combinations that do not induce significant compensation and can synergistically regulate fat deposition and muscle growth; designing expression vectors containing multiple guide RNA sequences to achieve simultaneous and precise editing; and obtaining edited individuals and validating the phenotype through embryonic or somatic cell nuclear transfer. This invention, through system-level multi-target synergistic editing, avoids metabolic imbalances, improves editing effectiveness, and promotes muscle development while reducing fat deposition, providing a safe and efficient technical path for precision breeding of cattle and sheep.

This invention belongs to the field of formulated feed technology for marine fish, specifically relating to a feed for improving the muscle quality of *Hexagrammos oysterfish* and its preparation method. The feed for improving the muscle quality of *Hexagrammos oysterfish* is made from the following raw materials in the indicated weight percentages: 93.5%–96.5% basic ingredients, 1% compound vitamins, 1% compound mineral salts, and 1.5%–4.5% formulated feed composition, with the sum of the weight percentages of all raw materials being 100%. The formulated feed composition consists of yeast β-glucan, chitosan oligosaccharide, and coated sodium butyrate, with the mass ratio of yeast β-glucan, chitosan oligosaccharide, and coated sodium butyrate being 1–3:1–3:1–2. This invention not only effectively reduces fat deposition in the body of *Hexagrammos oysterfish*, improving its muscle elasticity and chewiness, but also significantly improves the textural properties of the fish meat, thereby enhancing the overall muscle quality of *Hexagrammos oysterfish* and meeting consumer preferences.

The invention relates to application of a lotus plumule extract in preparation of drugs for activating Rab5a / PPARalpha signal axis, promoting fatty acid oxidation and reducing myocardial lipid toxicity injury. Animal experiments verify that the plumula nelumbinis extract effectively inhibits abnormal weight growth, reduces fat deposition, reconstructs fatty acid oxidative metabolism steady state, improves myocardial lipid toxicity injury and maintains cardiac functions by activating Rab5a / PPARalpha signal axis, and the plumula nelumbinis extract is stable in extraction process, clear in mechanism, small in toxic and side effects and easy to popularize. The problem that existing lipid metabolism abnormity intervention medicine targets and components are single can be solved, and a new scheme is provided for medicine research and development of metabolic diseases.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

The invention belongs to the technical field of biology, and discloses an Ileibacterium valens strain and application thereof.The Ileibacterium valens strain has the preservation number of GDMCC No: 67610, the preservation date of January 8, 2026, the classification name of Ileibacterium valens is named as Ileibacterium valens, the preservation unit is Guangdong Microbial Culture Collection Center, the preservation address is 59 building, No.100 Courtyard, Xianlie Middle Road, Guangzhou City, the Ileibacterium valens strain can obviously improve the ornithine level in the liver, and the content of ornithine in the liver can be obviously reduced. The traditional Chinese medicine composition has a certain improvement effect on metabolic disorder, hepatic lesion and fat deposition caused by MASLD induced by high-fat, high-glucose and high-cholesterol diet, and is expressed in that the levels of TC, LDL, AST and ALT in serum can be remarkably reduced.

The application provides a molecular marker related to a fat deposition trait of sheep and application thereof. TM The application is characterized in that the molecular marker is designed according to a primer of an ABCC3 gene sequence, DNA is extracted from sheep blood, and a A / T polymorphic site is found at the 354th bp of an amplified fragment through PCR amplification, DNA sequencing and sequence analysis, and the AQP TM The application is characterized in that the molecular marker is designed according to a primer of an ABCC3 gene sequence, DNA is extracted from sheep blood, and a A / T polymorphic site is found at the 354th bp of an amplified fragment through PCR amplification, DNA sequencing and sequence analysis, and the AQP TM The application is characterized in that the molecular marker is designed according to a primer of an ABCC3 gene sequence, DNA is extracted from sheep blood, and a A / T polymorphic site is found at the 354th bp of an amplified fragment through PCR amplification, DNA sequencing and sequence analysis, and the AQP

A method for reducing a subcutaneous fat deposit or a visceral fat deposit in vivo by contacting the fat deposit with a composition of latanoprost encapsulated in a liposome formed solely of egg phosphatidylcholine (EggPC) or palmitoyloleoyl phosphatidylcholine (POPC). Also disclosed are methods for treating steatoblepharon, proptosis, and obstructive sleep apnea associated with excess upper airway fat by injecting into the eyelid, intraconal space, and upper airway fat deposit, respectively, the composition of latanoprost encapsulated in an EggPC or POPC liposome.

The invention discloses application of aucubin in reducing fat deposition, and belongs to the field of biotechnology and animal husbandry application. The new application refers to application of aucubin in preparation of a composition for reducing fat deposition of non-human mammals. In particular, the composition can be used to induce and establish a standardized low fat deposition animal model or state, preferably a high fat diet induced obese mouse model (intragastric dose of 30 mg / kg body weight per day). In addition, the composition can also be used as a feed additive for non-human mammals. The aucubin is developed into a tool for constructing a standardized metabolism scientific research model for the first time, a brand new application scheme is provided for the aucubin as a safe and effective fat deposition regulating agent in livestock production, and the aucubin has important scientific research and industrial value.

The invention discloses an animal fat deposition regulation and control method based on an enterococcus faecium exosome and a preparation method of the animal fat deposition regulation and control method based on the enterococcus faecium exosome. According to the method, serine and glycine (with the concentration of 2-16 g / L) are additionally added into an enterococcus faecium culture medium to regulate the metabolic state of thalli, so that the exosome with specific biological activity is obtained. The exosome can be extracted by collecting enterococcus faecium culture supernatant and carrying out centrifugation, ultrafiltration and other steps. The obtained exosome can reduce fat deposition in an animal body, especially has a remarkable effect on reducing fat on the back of a fattening pig, and meanwhile, the exosome can serve as an effective component to be applied to products for preventing and treating animal obesity. The method has the advantages of simplicity in preparation, high safety and wide application prospect.

The present application relates to the field of medicine, and particularly relates to a traditional Chinese medicine composition for preventing, treating and improving non-alcoholic fatty liver, alcoholic fatty liver and obesity and application thereof; the composition is composed of chuanqiong, xiangfu, mayi, jineijin, baizhi, baicaoren, aloe or dahuang, cheqiancao, chixiaodou, meigui, yujin, wumei, biejia, zhizi and taizishen, based on the compatibility concept of "warm and hot dissolving, multi-target intervention", a three-dimensional treatment network of soothing liver and regulating qi, regulating qi and eliminating stagnation, moistening the intestines and defecation, promoting blood circulation to soften the liver and clearing heat and invigorating the spleen is constructed; the composition can be made into various oral preparations, and the animal test proves that the composition can effectively reduce liver fat deposition, improve liver function and related metabolic indicators, and has high safety, and is suitable for long-term conditioning.

The present application relates to the technical field of genetic engineering, in particular to a kind of gene medicine for treating PNPLA2 mutation arrhythmogenic cardiomyopathy and its preparation method and application.The effective component of gene medicine provided in the present application includes shuttle plasmid;The shuttle plasmid includes AAV9 carrier and PNPLA2 gene.The present application delivers normal PNPLA2 gene by AAV9 carrier, repairs the lipid metabolism disorder caused by mutation, reduces the fat deposition in myocardium, and then improves the pathological changes of ACM.By restoring the function of PNPLA2 gene, the process of myocardial fibrosis can be effectively inhibited, and the heart function can be improved.The present application uses myocardial specific promoter cTnT to ensure that PNPLA2 gene is only expressed in myocardium, so as to improve the targeting of gene therapy, and avoid the side effects caused by systemic expression.This strategy can effectively reduce the side effects of gene therapy, and ensure the accuracy and safety of treatment.

The invention discloses an anti-leptin monoclonal antibody 6B6 2E3 and application of the anti-leptin monoclonal antibody 6B6 2E3, and relates to the technical field of biology. The invention develops the anti-leptin monoclonal antibody 6B6 2E3, and the anti-leptin monoclonal antibody 6B6 2E3 can be used for effectively identifying leptin. The ELISA kit prepared by utilizing the monoclonal antibody 6B6 2E3 comprises indirect ELISA, and has the advantages of strong specificity and high sensitivity on a detection sample, convenient and efficient detection operation and low cost. Effective technical support is provided for research on regulation and control mechanisms of economic characters such as fowl ingestion, fat deposition and reproduction.