83 results about "Fatty Depositions" patented technology

The invention discloses a BMI-driven 3D organ obesity visualization system based on multi-modal fusion, and relates to the technical field of medical science, the system comprises a BMI-driven prediction model, the BMI-driven prediction model is used for establishing a quantitative mapping model of a BMI index and three-dimensional organ fat deposition, and the quantitative mapping model is used for establishing a BMI index and three-dimensional organ fat deposition. The BMI driving type prediction model comprises a multi-modal data fusion unit, a model mapping unit and a residual compensation unit. By installing the BMI driving type prediction model, precise nonlinear mapping of the BMI index and organ fat deposition is achieved, the problem that traditional single-mode prediction is large in deviation is solved, and organ fat volume prediction precision and individual difference adaptability are improved.

The application belongs to the field of intestinal microbiology, and discloses a new mucinophilic Akkermansia with improved obesity and glycolipid metabolism, wherein the mucinophilic Akkermansia strain is Akk-101 and AMY001. The preservation number of Akk-101 is CGMCC No. 40786, and the preservation number of AMY001 is CGMCC No. 46141. The Akk-101 and AMY001 strains in the application are different from standard strains in nucleotide consistency and physiological and biochemical indexes, have better acid-base tolerance and colonization capacity than the standard strains, can more effectively inhibit the accumulation of liver cell lipids, reduce the fat deposition in nematodes, and have the effects of weight loss and improvement of glycolipid metabolism, so that related products can be effectively developed based on the strains.

The invention belongs to the field of medicines, and discloses application of pyroglutamic acid in preparation of products for inhibiting fat deposition. The invention has the following advantages: 1, obesity induced by high fat diet is prevented; 2, pyroglutamic acid is a natural amino acid derivative, widely exists in animal and plant bodies, and has good biological safety; meanwhile, the invention further discloses a product for inhibiting fat deposition.

The invention belongs to the field of intestinal microbiology, and discloses a novel ackermania muciniphila capable of improving obesity and glycolipid metabolism, and the ackermania muciniphila strains are Akk-101 and AMY001. The preservation number of the Akk-101 is CGMCC (China General Microbiological Culture Collection Center) No. 40786, and the preservation number of the AMY001 is CGMCC No. 46141. The Akk-101 and AMY001 strains are different from standard strains in nucleotide consistency and physiological and biochemical indexes, have acid-base tolerance and colonization ability superior to those of the standard strains, and have the effects of more effectively inhibiting lipid accumulation of liver cells, reducing fat deposition in nematode bodies, losing weight and improving glycolipid metabolism. Therefore, related products can be effectively developed based on the strain.

The invention discloses application of an overexpressed carp lpla gene in regulation and control of expression of cyprinid fish tissue-related genes, and relates to the field of gene engineering, in particular to application of the overexpressed carp lpla gene in regulation and control of cyprinid fish tissue-related genes. The overexpressed carp lpla gene is applied to regulation and control of contents of lipid indexes of total cholesterol TC and triglyceride TG of different tissues of cyprinid fishes. The invention further discloses application of the overexpressed carp lpla gene in regulation and control of fat marker genes lpla, ppar gamma, Fabp3, fast and acaca of livers and muscle tissues of cyprinid fishes. The invention further discloses application of the overexpressed carp lpla gene in regulating and controlling the relative expression quantity of carp liver cell fat metabolism related genes lpla, ppar gamma, Fabp3, fast, acaca, hsl and pnpla2. The overexpressed carp lpla gene can regulate and control lipid deposition in different tissues in zebra fish, and a research model is provided for lpla to regulate and control fat deposition and differentiation. According to the overexpressed carp lpla gene disclosed by the invention, lpla high-expression carp hepatocytes are obtained through a liposome transfection technology, so that fat key gene expression in the carp hepatocytes is changed.

The invention provides an application of streptococcus salivarius in fatty liver, in particular to an application of streptococcus salivarius in preparation of a product, and the product is used for at least one of the following applications: (a) losing weight or reducing body fat; (b) improving the glucose tolerance of the patient; (c) increasing the sensitivity of the patient to insulin; (d) treating, relieving and preventing liver injury; (e) treating, relieving and preventing non-alcoholic steatohepatitis; (f) fat deposition caused by high-fat and high-cholesterol diet is reduced; (g) reducing blood fat; and / or (h) improving the level of at least one of the following indexes in the liver of the mammal: total cholesterol, triglyceride, low density lipoprotein-cholesterol and free fatty acid.

The invention belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to fermented lactobacillus mucus with an anti-aging function and application of the fermented lactobacillus mucus. The strain is preserved in Guangdong Microbial Culture Collection Center on August 27, 2025, and the preservation number is GDMCC No: 66877. Experimental results show that the bacterium has excellent oxidation resistance, can relieve oxidative damage, delay senescence and inhibit senescence-related gene expression, shows the capabilities of improving memory reproduction capability decline caused by senescence, improving body anti-inflammatory capability and improving intestinal flora imbalance induced by senescence, and can regulate fat factor level and improve energy metabolism, so that the function of resisting senescence is achieved. And the polypeptide shows the potential of resisting fat deposition and protecting liver functions. Therefore, the strain can be used for developing products with multiple beneficial functions of delaying senescence, contributing to resisting oxidation, assisting in improving memory, contributing to regulating intestinal flora and the like, has the advantages of high safety, strong gastrointestinal tract tolerance and good colonization ability, and has a very good application value.

This invention relates to the field of biomedical technology, specifically to the application of 6-ketolithocholic acid in the preparation of drugs that reduce fat deposition. The 6-ketolithocholic acid in this invention inhibits the accumulation of lipid droplets in adipocytes and suppresses gene expression in the PPARγ pathway involved in lipid synthesis, thereby achieving the function of reducing fat deposition. The structural formula of the 6-ketolithocholic acid is: [Insert structural formula here].

The invention provides an organoid culture medium, an organoid culture method and application of the organoid culture medium, the organoid culture medium comprises a first-stage culture medium, the first-stage culture medium comprises a first-stage basic culture medium and first-stage addition factors, and the first-stage addition factors comprise N-acetylcysteine, nicotinamide, a ROCK inhibitor, Noggin, R-spondin, EGF, HGF, Gastrin, FGF10, Blebbistatin, Forskolin, A83-01, LDN193189, DAPT, TGF-alpha and UDAC. By using the organoid culture medium, the liver organoid and the fatty liver organoid can be effectively obtained, and the obtained fatty liver organoid has obvious fat deposition, is sensitive to fatty liver treatment drugs, highly restores the physiological status when human body fatty liver diseases occur, and has high application value.

The application belongs to the technical field of microorganisms and fermentation engineering, and particularly relates to a fermented Lactobacillus muci genus with a function of delaying aging and application thereof. The bacterium was preserved in the Guangdong Microbial Culture Collection Center on August 27, 2025, and the preservation number is GDMCC No: 66877. Experimental results show that the bacterium has excellent antioxidant performance, can relieve oxidative damage, delay aging, inhibit the expression of aging-related genes, and has the ability to improve the memory reproduction ability decline caused by aging, improve the body's anti-inflammatory ability, improve the intestinal flora imbalance induced by aging, and can regulate the level of fat factors, improve energy metabolism, and has the potential of anti-fat deposition and protection of liver function. Therefore, the bacterium can be used to develop products with multiple beneficial functions such as delaying aging, helping to antioxidant, auxiliary improving memory, helping to regulate intestinal flora, and has the advantages of high safety, strong gastrointestinal tolerance, good colonization ability, and has good application value.

The invention discloses a composition for dispelling effects of alcohol and protecting liver as well as a preparation method and application thereof. The composition is prepared from the following raw material medicines: 30-50 parts of oyster peptide, 50-100 parts of radix puerariae, 50-100 parts of hovenia dulcis thunb, 20-30 parts of chrysanthemum, 20-30 parts of endothelium corneum gigeriae galli, 20-30 parts of malt, 20-30 parts of pericarpium citri reticulatae, 20-30 parts of liquorice, 20-30 parts of fructus lycii, 10-20 parts of red dates, 10-20 parts of American ginseng and 10-20 parts of corn oligopeptide. Pharmacodynamic tests show that the composition can significantly reduce drunkenness time, improve activity of ethanol-related metabolic enzymes, reduce levels of serum ALT, AST and ALP induced by acute alcoholic liver injury, enhance expressions of various antioxidant systems in liver tissues, significantly inhibit secretion level of inflammatory factors in serum, and improve liver injury resistance. Meanwhile, hepatic lesions and fat deposition are relieved at a histological level, so that the composition disclosed by the invention has obvious functions of dispelling the effects of alcohol and protecting the liver through scientific proportioning and synergistic interaction of the raw materials.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

This invention discloses anti-leptin monoclonal antibodies and their applications, relating to the field of biotechnology. This invention develops anti-leptin monoclonal antibodies 2A122H7 and 6B62E3, which can effectively recognize leptin. The ELISA kits prepared using these monoclonal antibodies 2A122H7 and 6B62E3 include indirect ELISA and double-antibody sandwich ELISA kits, exhibiting high specificity and sensitivity for the tested samples, and are convenient, efficient, and cost-effective. This invention provides effective technical support for advancing research on the regulatory mechanisms of economic traits such as feed intake, fat deposition, and reproduction in poultry.

The application provides a molecular marker related to tail fat deposition of sheep, a detection method and application thereof. Through PCR amplification and sequence analysis of rBAT (SLC3A1) gene of the sheep, a C / T polymorphic site at the 689th position of the amplified fragment is found, further, the polymorphic site of 1286 Hu sheep is detected by using KASPar primers, a least square model is established, and correlation analysis of the genotypes and growth traits is carried out, and finally it is determined that the amplified RBAT gene fragment can be used as a molecular marker related to tail fat of the sheep. The application can be used for selecting and reserving TT homozygous sheep into a core group, for reducing tail fat deposition of the sheep, and for increasing economic benefits.

Systems and methods for treating cellulite including an apparatus that applies or a method involving separating septa to eliminate or reduce the appearance of cellulite. In one approach, an interventional tool is placed between tissue layers to engage and treat septa connecting tissue layers between which fat deposits are contained.

This invention provides the application of a *Breago brevis* strain in the preparation of products that promote intramuscular fat deposition in livestock and poultry. The *Breago brevis* strain is *Breago brevis* JCM 32280. Under high-fiber dietary conditions, supplementation with *Breago brevis* JCM 32280 of this invention can efficiently degrade fiber to produce high concentrations of butyrate. Butyrate, as a key effector molecule, can directly bind to and activate PPARγ receptors in host cells, thereby upregulating the MOGAT2-mediated triglyceride synthesis pathway, significantly increasing body fat percentage in mammals and promoting intramuscular fat (marbling). Simultaneously, this strain can reshape the intestinal microecology, specifically increasing the abundance of beneficial intestinal lactobacilli and enhancing the intestinal mucus barrier, providing a safe and efficient microbial preparation strategy for improving the fat deposition capacity and meat flavor of livestock and poultry.

The invention relates to the technical field of poultry health assessment, in particular to a method for predicting and identifying the high fat deposition risk of the liver of a laying hen based on blood amino acid parameters. The method comprises the following steps: collecting a blood sample when the laying hen is in a metabolic state after absorption, detecting the total amino acid content and the alanine content in blood, and substituting blood parameters into a pre-established liver triglyceride prediction model to obtain the predicted liver triglyceride content, and comparing the prediction results to judge the high fat deposition risk of the liver of the laying hen. According to the method, the laying hens do not need to be slaughtered and sampled, the fat deposition state of the livers of the living laying hens can be rapidly evaluated, and the method is suitable for early screening and risk early warning of high fat deposition of the livers of the laying hens under the large-scale breeding condition.

The invention discloses application of a pig SOS1 gene in regulation and control of adipocyte differentiation, and relates to the technical field of biology. An overexpression system is constructed by exogenously introducing a swine SOS1 gene into 3T3-L1 precursor fat cells of a mouse, and the influence of the overexpression system on adipogenic differentiation of the cells is detected; researches find that the overexpression of the pig SOS1 gene significantly promotes the adipogenic differentiation of 3T3-L1 cells of mice, and improves the mRNA and protein expression levels of key adipogenic markers PPAR gamma, FABP4 and HSL. The invention provides a theoretical basis for improving the fat deposition character of the pig.

The invention discloses application of an Fn1-PPARbeta / delta signal channel related to a cardiac liver disease. The cardiac liver disease model is constructed according to the conditions that the liver development of young individuals is delayed due to heart injury and both adult and young individuals have serious fatty livers. In the model, the Fn1 protein level in the heart and blood is obviously increased compared with the normal level. Based on a zebra fish heart ablation means, after heart ablation injury, the heart specific knock-down Fn1 can lead to reduction of the Fn1 protein level in blood and alleviation of liver development retardation and fat deposition. Through the screening of transcriptomics, the PPARbeta / delta protein in the liver is found to be a potential downstream effect factor of Fn1. The liver specific overexpression PPARbeta / delta protein can significantly relieve abnormal phenotypes such as liver fat deposition caused by heart injury, and after the liver specific knock-down PPARbeta / delta protein, the protection effect of knock-down Fn1 on the liver disappears under the condition of heart injury. Therefore, the Fn1 protein and the PPARbeta / delta protein can be used as targets for preventing and treating the cardiac liver injury, and are used for preparing medicines for improving the cardiac liver injury, so that a new way is provided for treating the cardiac liver disease.

The application belongs to the technical field of poultry breeding, and discloses siRNA for targeted inhibition of chicken PLCD4 gene expression and application thereof; the siRNA comprises PLCD4-853, PLCD4-528 and PLCD4-1870; the siRNA for targeted inhibition of chicken PLCD4 gene expression can effectively reduce the expression of the chicken PLCD4 gene after being introduced into chicken primary subcutaneous adipocytes, and the inhibition efficiency is more than 50%, and the knockdown efficiency is very high; the siRNA can be used for identifying gene functions by specifically knocking down the expression of the chicken PLCD4 gene in vitro, and can be applied to genetic selection of high-quality broiler subcutaneous fat deposition as a molecular marker, and has great economic value and scientific research value.

The invention belongs to the technical field of molecular genetics, and particularly relates to an SNP (Single Nucleotide Polymorphism) marker related to identification of sheep tail fat deposition and application of the SNP marker, and the SNP molecular marker is located at the 4146459th nucleotide site C / A mutation on the No.15 chromosome of AR-UIRamv3.0 reference genome (GCF016772045.2). The technology has the advantages of high accuracy, high detection speed, low cost, easiness in result judgment and the like. The SNP locus detection is used for carrying out thin tail type sheep early selection, shortening the breeding period and accelerating the breeding process, an fat tail type sheep early selection technology is established, the breeding time of fat tail type sheep with excellent characters is shortened, the breeding cost is reduced, and the application value is very high.

The invention belongs to the technical field of molecular biology, and relates to miRNA for regulating and controlling the content of fat and / or unsaturated fatty acid in buffalo muscle and application of the miRNA. The miRNA is miR-30f (bta-miR-30f), and the fat deposition in the buffalo muscle and the composition of unsaturated fatty acid are influenced by regulating and controlling the expression of an RAD23B gene. The invention finds that transfection of a bta-miR-30f simulant in buffalo intramuscular fat cells can significantly improve intramuscular fat content and unsaturated fatty acid proportion, while transfection of an inhibitor shows a reverse effect. Further research finds that knock-down of the RAD23B gene can also increase the content of triglyceride and unsaturated fatty acid in buffalo muscle tissue. Important gene resources and molecular breeding technical means are provided for genetic improvement of buffalo meat quality characters (including flavor characteristics and nutritional value).

Systems and methods for treating cellulite, including apparatus applying or methods involving separating a membrane to eliminate or reduce cellulite appearance. In one method, an interventional tool is placed between tissue layers to act and treat septums connecting the tissue layers containing fat deposits therebetween.

The application discloses a hypoglycemic and hypolipidemic composition from the leaves of pandamus, a preparation method and application thereof. The composition contains p-coumaric acid, rutin, kaempferol-3-O-rutinoside, pandamarilactonine-A, pandamarilactone-1 and pandamarilactone-2. The composition with a preferred mass ratio has a certain synergistic effect. Under the premise of a consistent total dose, the composition is superior to p-coumaric acid, rutin and kaempferol-3-O-rutinoside in improving insulin resistance and reducing fat deposition, and is also superior to a pandamus alkaloid composition composed of pandamarilactonine-A, pandamarilactone-1 and pandamarilactone-2, which indicates that there is a synergistic effect among the components of the composition.

The invention relates to the technical field of molecular biology, in particular to siRNA for interfering LRP6 as well as a product and application thereof. The nucleotide sequence of the siRNA for interfering with the LRP6 is shown as SEQ ID NO.1-8. The invention also discloses a preparation method of the siRNA. After an interference fragment of the LRP6 is obtained through screening, cell transfection is carried out, the LRP6 is interfered through siRNA, it is revealed that the interference LRP6 significantly inhibits the activity of subpigskin precursor fat cells and promotes differentiation and adipogenesis of the subpigskin precursor fat cells, it is revealed that the LRP6 can positively regulate and control proliferation of the subpigskin precursor fat cells and negatively regulate and control adipogenesis, a reference is provided for optimizing the pig fat deposition efficiency, and the application of the LRP6 in the field of pig fat deposition is provided. Effective functional genes are provided for pork quality character breeding, and effective targets are provided for high-quality pork pigs.

The application relates to a mutant type of an INSIG1 gene for regulating fat deposition of animals and application thereof, wherein the mutation is located at the 3725th base of a nucleotide sequence shown in SEQ ID NO. 1, and is an A>G single nucleotide mutation. The application analyzes the genetic basis of fat deposition of animals by using comparative genomics, finds that a strictly conserved site of an INSIG1 gene corresponds to parallel replacement of histidine to arginine of amino acids, and the potential function of the strictly conserved site in fat deposition and mobilization is prompted.

The invention belongs to the technical field of nutritional compositions and biological medicines, and particularly relates to a composition with a liver protection effect as well as a preparation method, application and a product thereof. The composition disclosed by the invention is prepared from Akkermania muciniphila and a globe artichoke extract, wherein the weight ratio of the Akkermania muciniphila to the globe artichoke extract is (1 to 8) to (1.6 to 10). The composition disclosed by the invention has a protection effect on various liver injuries such as alcoholic liver injury, chemical liver injury and non-alcoholic fatty liver injury, is obviously superior to a single bacterial preparation, a single globe artichoke extract and an existing conventional liver protection product, and can effectively reduce the levels of ALT and AST in serum, reduce liver fat deposition, inhibit liver inflammatory response and realize a liver protection effect.

This invention relates to the fields of gene editing and animal genetic breeding technology, and discloses a precise editing method for key genes regulating lipid metabolism in cattle and sheep. The method includes: constructing a comprehensive lipid metabolism network map integrating transcriptomic, proteomic, and metabolomic data; using a graph neural network to identify key node genes with high flow weights and their negative feedback pathways; simulating cascade reactions after gene perturbation to assess compensatory effects; screening for multi-gene combinations that do not induce significant compensation and can synergistically regulate fat deposition and muscle growth; designing expression vectors containing multiple guide RNA sequences to achieve simultaneous and precise editing; and obtaining edited individuals and validating the phenotype through embryonic or somatic cell nuclear transfer. This invention, through system-level multi-target synergistic editing, avoids metabolic imbalances, improves editing effectiveness, and promotes muscle development while reducing fat deposition, providing a safe and efficient technical path for precision breeding of cattle and sheep.

This invention belongs to the field of formulated feed technology for marine fish, specifically relating to a feed for improving the muscle quality of *Hexagrammos oysterfish* and its preparation method. The feed for improving the muscle quality of *Hexagrammos oysterfish* is made from the following raw materials in the indicated weight percentages: 93.5%–96.5% basic ingredients, 1% compound vitamins, 1% compound mineral salts, and 1.5%–4.5% formulated feed composition, with the sum of the weight percentages of all raw materials being 100%. The formulated feed composition consists of yeast β-glucan, chitosan oligosaccharide, and coated sodium butyrate, with the mass ratio of yeast β-glucan, chitosan oligosaccharide, and coated sodium butyrate being 1–3:1–3:1–2. This invention not only effectively reduces fat deposition in the body of *Hexagrammos oysterfish*, improving its muscle elasticity and chewiness, but also significantly improves the textural properties of the fish meat, thereby enhancing the overall muscle quality of *Hexagrammos oysterfish* and meeting consumer preferences.