The invention discloses an intelligent coagulation dosing method and device for a water purification plant, belongs to the technical field of coagulation in water purification production, and aims to solve the problems of poor anti-interference capability, high requirements on water quality and process conditions, troublesome adjustment and difficult maintenance for various water quality parameters. The method is based on collection of water plant operation big data. Non-linear modeling and non-linear prediction are carried out on the coagulation dosing process, the influence of system time lag is reduced through prediction control, the influence of raw water quality disturbance and model mismatch on a control system is eliminated, the dosing control precision and the robustness of the system are improved, and the purpose of intelligent dosing is achieved. The control model can overcome the main problem that an existing automatic dosing system is inaccurate in prediction, has high self-adaptive capacity, explores a new way for water plant coagulation dosing control, provides reliable basis for implementation of next coagulation dosing control, meanwhile, the dosing optimization method of the scheme is applied, the water quality assurance rate is increased, the labor is saved, and the coagulant cost is reduced.