The invention discloses a magnetic control piezoelectric / topological double-layer heterogeneous biological functionalized nerve
scaffold as well as a preparation method and application thereof. The preparation method comprises the following steps: respectively carrying out
surface modification on
magnetic nanoparticles and piezoelectric nanoparticles; dispersing the modified
magnetic nanoparticles and piezoelectric nanoparticles in an inner-layer biological material solution to obtain an inner-layer
spinning solution; dispersing a therapeutic
drug into the outer-layer biological material solution to obtain an outer-layer
spinning solution; the preparation method comprises the following steps: firstly,
processing an inner-layer
spinning solution to form an inner-layer
fiber layer with an anisotropic topological structure; then switching to outer-layer spinning solution, and forming an outer-layer
fiber layer with a disordered structure on the inner-layer
fiber layer through an in-situ deposition method, so as to obtain a double-layer
stent; and washing and
drying the double-layer
stent. According to the double-layer
stent, a magnetic control
piezoelectric coupling mechanism is adopted, an in-situ electrical stimulation and heterogeneous double-layer structure is generated through driving of an external
magnetic field, and space-time cooperation of physical guidance and biochemical signals is achieved.