The invention relates to an image information processing technology, and provides an ultrahigh resolution panorama speed dome AIO (All-In-One) system, a video stitching method and a spatial registration method of the ultrahigh resolution panorama speed dome AIO system. A device comprises an engine base element, a panorama stitching video camera comprising multiple cameras, a speed dome, a controller, a shell and a support. The video stitching method comprises the steps of lookup table calculation, stitching line calculation, image fusion and the like. The spatial registration method comprises the steps of establishing a panorama stitching image coordinate system, uniformly dividing a panorama stitching image into a plurality of rectangular regions, sampling, calculating a mapping relation of sampling points and calculating a non-sampling point mapping relation by adopting a bilinear interpolation method. According to the ultrahigh resolution panorama speed dome AIO system, the video stitching method and the spatial registration method, provided by the invention, not only can panorama monitoring be realized, but also a high-resolution monitoring scene can be provided at the same time, and quick and accurate focus location, zoom out and zoom in and quick and stable browsing of an interested target can be realized through registration linkage between a panorama real-time stitching camera and the speed dome.