The invention discloses a PPR / EVOH / POE (Pentatricopeptide Repeats / Ethylene-Vinyl Alcohol / Polyolefin Elastomer) blending high-impact barrier pipe and a manufacturing method thereof, belonging to the field of novel polymeric composite materials. A blending system is formed through physical blending by compositely using PPR, EVOH and POE and compatibilization is carried out on the blending system byadopting a PP-g-MAH (Polypropylene-grafting-Maleic Anhydride) nucleating agent, thus the problems of low temperature brittleness, oxygen and permeability resistance, corrosion resistance, ageing resistance, heat resistance, processability, and the like of a PPR pipe are effectively solved. The PPR / EVOH / POE blending high-impact barrier pipe has the following performances that: drawing yield pressure is 48 MPa, the impact strength of a freely supported beam is 3.6 KJ / m<2>, and oil absorption rate is 0.5%, longitudinal retraction rate is 1%; seepage and crack do not exist in hydrostatic tests and heat stability tests in hydrostatic states; and the PPR / EVOH / POE blending high-impact barrier pipe meets the safety evaluation criterion of domestic drinking water delivery and distribution equipment and protective materials. The invention can be widely applied to the fields of municipal and building water supply, heating, gas supply, electric power, communication, industry, agriculture, and thelike.