The invention discloses a biomass-oil catalytic hydrogenation reaction device. The biomass-oil catalytic hydrogenation reaction device comprises a reaction tower, a lift pipe fixed in the inner cavity of the reaction tower through a support, a temperature sensing probe arranged in the inner cavity of the reaction tower, a catalyst reactivation device, a gas-liquid separator, a hydrogen source, a biomass crude oil storage tank, an oil transfer pump, a refined oil product storage tank, a flow control device, a first electromagnetic valve, a second electromagnetic valve, a third electromagnetic valve, a first compressor, a second compressor, a first heat exchanger and a second heat exchanger. The invention also discloses a catalytic hydrogenation method of the biomass-oil catalytic hydrogenation reaction device, wherein the catalytic hydrogenation method comprises the steps of cooling hydrogen circulation, reactive hydrogen circulation, a catalyst reactivation circulation, and regulation and control on biomass oil channel and hydrogen flow. The biomass-oil catalytic hydrogenation reaction device solves the temperature control problem in the catalytic hydrogenation reaction, the heat dissipation problem and the immediate reactivation problem of the deactivated catalyst.