The invention discloses a negative pressure drainage system capable of achieving a self-circulation; the negative pressure drainage system can generate a continuous liquid shearing force in the position of a wound surface, so as to accelerate the union of the wound surface. The negative pressure drainage system comprises a medical dressing, a waste liquid bottle, a vacuum pump, an A liquid conduit, an A air conduit, a B liquid conduit, a peristaltic pump, a C liquid conduit, an infusion bottle, an E liquid conduit, an a control valve, a B control valve and an F control valve, wherein the medical dressing, the B liquid conduit, the peristaltic pump, the C liquid conduit and the infusion bottle are sequentially connected. The medical dressing, the A fluid conduit, the waste liquid bottle, the A air conduit and the vacuum pump are sequentially connected. The E liquid conduit is connected between the C liquid conduit and the A liquid conduit. The A control valve is installed on the A liquid conduit; and the connection point between the E liquid conduit and the A liquid conduit is located between the A control valve and the medical dressing. The B control valve is installed on the C liquid conduit; and the connection point between the E liquid conduit and the C liquid conduit is located between the B control valve and the peristaltic pump. The F control valve is installed on the E liquid conduit.