The invention discloses a seed treatment agent composition and applications thereof, and relates to the technical field of pesticide compounding. The seed treatment composition contains an active component A, an active component B and an active component C, wherein the active component A is prothioconazole, the active component B is imidacloprid, the active component C is chlorpyrifos, and a weight ratio of the active component A to the active component B to the active component C is 1-30:1-30:1-30. According to the present invention, the seed treatment agent can act from different target points, can kill insects and sterilize, can provide all-round protection for seeds, has advantages of good environmental compatibility, low toxicity and safety to humans, animals, natural enemies and other organisms, belongs to the broad-spectrum efficient seed treatment composition, has the high synergistic effect, can reduce the application cost, has the prevention and control effect significantly superior to the use of the single agent, and has obvious promotion value.