The invention discloses an information security chip of the Internet of Things. The chip comprises a central processor, a dynamic memory, a flash memory, an SM2 encryption algorithm unit, an SM3 encryption algorithm unit, an SM4 encryption algorithm unit, an AES encryption algorithm unit, a true random number generator, a physical unclonable function circuit, an I2C interface, a UART interface, anSPI interface, an I/O interface, a JTAG interface and a timer which are interconnected through an on-chip bus. The true random number generator is used for generating true random numbers; The physical unclonable function circuit is used for chip authentication and key generation, when a key needs to be used, a true random number generated by the true random number generator is input into the physical unclonable function circuit through an on-chip bus, the physical unclonable function circuit outputs a unique response sequence, and the response sequence is the key. The encryption and decryption operation speed is high, the hardware resource consumption is low, the power consumption is low, the secret key cannot be copied and stolen, and the security and anti-counterfeiting level is high.