The invention discloses a method and device for eliminating clock jitter in analog-to-digital conversion and a digital pre-distortion method and relates to the pre-distortion technology in the communication field. The method for eliminating clock jitter in analog-to-digital conversion is characterized by comprising the steps that step 1, an analog signal z (t) is received; step 2, a clock signal h (t) is offered to an analog-to-digital conversion module, meanwhile, an arithmetic product of the clock signal h (t) and a single-tone signal m (t) serves as a reference signal q (t) and is added to the analog signal z (t), so that a composite signal r (t) is obtained; step 3, analog-to-digital conversion is conducted on the composite signal r (t) through the analog-to-digital conversion module, so that two completely identical composite signals rjit (n) are obtained; step 4, after a jitter sequence of one of the two composite signals rjit (n) is estimated, a clock jitter sequence is obtained; step 5, clock jitter elimination is conducted on the other of the two composite signals rjit (n) through clock jitter sequence, so that a purified digital signal y (n) with clock jitter eliminated is obtained.