The invention relates to the field of metal continuous casting manufacturing, in particular to a method for producing an ultra-thick plate continuous casting blank by adopting fast cooling and unsymmetrical great pressing-down. According to the method, a continuous casting blank sequentially passes through a vertical section (2), an arc-shaped section (3), a straightening section (4) and a horizontal section (5) under a crystallizer (1), through the implementation of fast cooling and unsymmetrical great pressing-down in a secondary cooling region of a casting machine, the ferritiszation process of the casting blank surface layer is realized before the bending or straightening through the fast cooling process, in addition, the balanced separation of second-phase particles in crystals and at crystal boundaries is ensured, the surface layer tissues of the casting blank are improved, meanwhile, the deformation of a blank core part can be increased through the unsymmetrical great pressing-down process, the occurrence of surface cracks of medium and ultra-thick casting blanks in the bending and straightening process is prevented, and meanwhile, the center segregation and the center looseness of the ultra-thick casting blank is avoided. The method provided by the invention has the advantages that the surface quality and the center quality of the ultra-thick plate continuous casting plate can be better improved, so that the ultra-thick plate continuous casting blank can realize the rolling production of ultra-thick steel plates with the thickness being greater than 120mm at a low compression ratio.