The invention relates to a harmonicon which can conveniently change tones. The harmonicon comprises a sound grid board, articulating units and a sliding part, and repeating units which are formed by an upper-line blowing holes and a lower-line blowing holes is arranged on the sliding parts. The sound boards of two different pitch arrangements are arranged in the harmonicon, wherein, the pitch of the articulating units of one sound board is arranged by intercepting one section from the following arrangement sequence: B4, C3, D3, F3, G3, A3, B3 ellipsis c, d, f, g, a and b ellipsis; and the pitch of the articulating units of the other sound board is arranged by intercepting one section from the following arrangement sequence: C3, D3, E3, F3, G3, A3 ellipsis c, d, e, f, g and a, etc. The sound boards of two different pitch arrangements match the sound grid board to form an upper-lower superposition structure. The repeating units are arranged by each six holes which neighbor mutually on both left and right on the sliding part, and at least one positioning cut is arranged on the sliding part, and a positioning part which matches the positioning cut and remove and replace the sliding part is arranged on the harmonicon. The invention is suitable for being played as one harmonicon.