A centrifugal compressor for a heavy oil hydrogenation device is composed of the four parts of a stator assembly, a rotor assembly, a bearing group and dry gas seals. The stator assembly comprises a cylinder block, end covers, partition plates and a seal. The rotor assembly comprises 6-8 impellers, a main shaft, spacer sleeves, a balance disk, a thrust disk, nuts, an adjusting pad and a stopper ring. The bearing group comprises two supporting bearings and a thrust bearing. The dry gas seals are provided with independent control units and independent systems and each comprises a body and a control portion. The centrifugal compressor for the heavy oil hydrogenation device is characterized in that (1) the compressor is of a vertical subdivision type structure; (2) the partition plates are assembled together to form a partition plate bundle, and a bladeless diffuser is arranged between every two adjacent partition plates; (3) the 6-8 impellers are sequentially arranged on the main shaft, and the diameter of each impeller is 400 mm; (4) the blade forms of the impellers are identical, and the blades of one impeller deviate by a certain angle relative to the blades of the impeller locatedin the front; (5) the supporting bearings are titling-pad bearings, the thrust bearing is of the Kingsbury type, and the two sides of the thrust bearing are of the same structure; (6) the dry gas seals are installed at the two ends of the compressor, and the dry gas seals are provided with the independent control systems.