The invention relates to the technical field of casting equipment, and discloses a vertical squeeze casting machine. The machine comprises a mold opening and closing device and an injection device, the mold opening and closing device comprises a rear mold plate, a fixed mold plate, a movable mold plate, an opening and closing assembly and a liquid filling assembly, in the casting process, the opening and closing assembly drives the movable mold plate to conduct mold closing or mold opening, and rapid mold locking is achieved; and in the mold closing state, the liquid filling assembly can conduct pressurization mold locking on the movable mold plate, the opening and closing assembly and the liquid filling assembly are separately controlled, the mold opening and closing time is greatly shortened, and the production efficiency is improved. The injection device comprises a base, an injection assembly and a feeding assembly, the fixed mold plate is provided with a liquid inlet in butt jointwith the injection assembly, and the injection assembly reciprocates between the feeding assembly and the liquid inlet. The feeding assembly independently provides molten metal for the injection assembly, then the injection assembly injects the molten metal into a metal impression to complete casting, the flowing path is short, gas is located on the molten metal, the gas entrapment phenomenon isreduced through injection from bottom to top, and the product quality is improved.