The embodiment of the present invention discloses a power supply control circuit and method of a mobile terminal and a power supply management module. The power supply control circuit comprises an external power supply input end, a battery, a voltage conversion module, a first switch, a mainboard, the power supply management module, a voltage comparison module, a switch control module and a voltage stabilization capacitor. The voltage comparison module and the power supply management module are connected with the switch control module, and the switch control module is connected with the first switch. The switch control module is used to control the first switch to connect an external power supply circuit if the voltage comparison module determines that an external power supply inputted by the external power supply input end satisfies a threshold condition, and the power supply management module outputs an instruction for connecting the external power supply circuit, so that the battery does not supply power, the situation that the battery is charged while discharging can be reduced, the charge and discharge times of the battery can be reduced, and the service life of the battery is prolonged. Otherwise, the switch control module is used to control the first switch to connect a battery power supply circuit, thereby guaranteeing the power supply continuity to the mobile terminal.