44 results about "Melanin precursors" patented technology

The present invention features a polymer for darkening the skin. The polymer comprises repeating units derived from melanin precursors and amine-comonomers. The polymer may be combined with a cosmetically acceptable carriers to form topical compositions. Methods of darkening the skin are also provided.

The invention essentially consists in the use of melanins, melanin precursors or melanin derivatives, melanin variants, melanin analogues, natural or synthetic, pure or mixed with organic or inorganic compounds, metals, ions, drugs; as water electrolyzing material, using as sole or main source of energy, natural or synthetic light, coherent or not; in the systems of hydrogen production from water, known as photoelectrochemical systems. These systems integrate as semiconductor material and a water electrolyzer inside a monolithic design, to produce hydrogen directly from water, using light (between 200 to 900 nm) as the main or sole source of energy. At least to basic criteria had to be met: one was that the system or light absorbing compound should generate enough energy to start, lead and complete the photoelectrolysis reaction, being economical, stable and lasting in a water system, requirements met by melanins, representing thus an important and critical advance to solve the central problem of photoelectrochemical designs. The procedure can be applied to generate hydrogen, oxygen and high energy electrons, or the opposite sense, i.e., synthesizing water from the union of hydrogen and oxygen, generating electricity; it can be coupled to other processes, generating a multiplication effect; it can also be used for reduction of carbon dioxide, nitrates and sulphates or others.

Provided are a melanin having excellent dyeability on a functional film, and good reproducibility and storage stability, and a method for producing the same. In addition, it also provides a melanin-containing functional film which contains the melanin of the present invention, improves the fluctuation of melanin, and has excellent performance in protecting eyes from ultraviolet rays, and a production method thereof. The method for producing melanin according to the present invention includes at least an oxidation reaction step of continuously oxidizing the above-mentioned melanin precursor while maintaining a constant molar ratio of the melanin precursor to an oxidizing agent in an alkaline aqueous solution, and after the oxidation reaction step The reaction liquid becomes acidic and the precipitation process of melanin is precipitated. In addition, the method for producing a functional film containing melanin of the present invention includes at least a step of treating the film with an alkaline aqueous solution containing the melanin, and a step of treating the film treated with the alkaline aqueous solution with an aqueous solution containing an inorganic salt.

An air-oxidative type hair dye composition containing a melanin precursor prepared by a process including (A) an oxidation step for converting, into the melanin precursor, a tyrosine or derivative thereof used as a starting substance with an enzyme or cell that is derived from a fungus selected from the group consisting of fungi belonging to the genera Aspergillus, Neurospora, Rhizomucor, Trichoderma, and Penicillium and that exhibits a catechol oxidase activity.

The invention discloses a double-agent melanin precursor hair dye and a three-agent melanin precursor hair dye. The double-agent melanin precursor hair dye comprises an agent A and an agent B; the three-agent melanin precursor hair dye comprises an agent A, an agent B and an agent C; the agent A and the agent C both comprises melanin precursors, common hair dye auxiliaries and water; the common hair dye auxiliaries refer to one or more of a wetting agent, a thickening agent, a surfactant, a moisturizing agent and a pH value regulating agent. By combination of advantages of chemical synthesized hair dye and natural hair dye, compound enzyme liquor in natural edible fungi is extracted, amino acids are subjected to bioconversion to synthesize melanin precursor substances such as hallachrome, 5,6-dyhydroxyindole and 5,6-dyhydroxyindole-2-carboxylic acid, skin irritation and allergization are avoided, high safety is achieved, and natural black hair dyeing effects are kept. In addition, due to various agent type choices, the multi-agent melanin precursor hair dye has a great popularization and application value in the field of hair dye preparation.

The invention discloses a method for preparing a water-soluble plant melanin. The method comprises the following steps of preparing a melanin precursor from blueberry leaves as raw materials and carrying out enzyme catalytic oxidation, macroporous resin purification and spray drying to obtain the water-soluble plant melanin. The water-soluble plant melanin obtained by the method has good water-solubility and solves the problem that a natural melanin cannot be dissolved in water.

The invention discloses a melanin precursor substance hair dye. The melanin precursor substance hair dye consists of a melanin precursor, a common hair dye adjuvant and water, wherein the melanin precursor includes dopachrome, 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid; the melanin precursor accounts for 0.01-5% of the hair dye in percentage by weight; and the common hair dye adjuvant includes one or more of a wetting penetrating agent, a thickening agent, a surfactant, a moisturizer and a pH value regulating agent. The hair dye disclosed by the invention combines the advantages of a chemically synthetic hair dye and a natural hair dye; by extracting complex enzyme liquid in natural edible fungi, such melanin precursor substances as the dopachrome, the 5,6-dihydroxyindole, the 5,6-dihydroxyindole-2-carboxylic acid and the like are synthesized through bio-conversion by virtue of amino acid, so that the hair dye is free from irritation and allergy to skin, high in safety and capable of keeping a natural black hair dyeing effect; and the hair dye has huge popularization and application values in the field of the preparation of hair dyes.

The invention belongs to the field of special cosmetics, and particularly relates to a single-agent-type hair colorant. The single-agent-type hair colorant comprises a melanin precursor and is characterized in that the melanin precursor is prepared from, by weight, 70-85% of 5,6-dihydroxyindole, 5-10% of 5,6-dihydroxyindole-2-carboxylic acid, 5-10% of 5,6-dihydroxyindoline and 5-10% of 5,6-dihydroxyindoline-2-carboxylic acid. The obtained single-agent-type hair colorant is high in safety, and the melanin precursor is good in hair coloring effect and high in colorability.

The invention essentially consists in the use of melanins, melanin precursors or melanin derivatives, melanin variants, melanin analogues, natural or synthetic, pure or mixed with organic or inorganic compounds, metals, ions, drugs; as water electrolyzing material, using as sole or main source of energy, natural or synthetic light, coherent or not; in the systems of hydrogen production from water, known as photoelectrochemical systems. These systems integrate as semiconductor material and a water electrolyzer inside a monolithic design, to produce hydrogen directly from water, using light (between 200 to 900 nm) as the main or sole source of energy. At least to basic criteria had to be met: one was that the system or light absorbing compound should generate enough energy to start, lead and complete the photoelectrolysis reaction, being economical, stable and lasting in a water system, requirements met by melanins, representing thus an important and critical advance to solve the central problem of photoelectrochemical designs. The procedure can be applied to generate hydrogen, oxygen and high energy electrons, or the opposite sense, i.e., synthesizing water from the union of hydrogen and oxygen, generating electricity; it can be coupled to other processes, generating a multiplication effect; it can also be used for reduction of carbon dioxide, nitrates and sulphates or others.

The invention discloses a preparation method for melanin. The preparation method comprises the following steps: adding a melanin precursor, a surfactant and an oxidant into a polymer solution respectively; regulating the pH (Potential of Hydrogen) value to be 7 to 13; and while stirring, carrying out an oxidization reaction to prepare the melanin, wherein the mol ratio of the melanin precursor to the oxidant is 1 to (0.1 to 10), the concentration of a water-soluble polymer is 0.01% to 5% and the concentration of the surfactant is 0.01% to 2%. The melanin prepared by the preparation method has a relatively small particle diameter; and a functional thin film prepared by utilizing melanin granules prepared by the preparation method has a strong ultraviolet shielding function and has high visible light transmittance.

The present invention provides a melanin that is excellent in coloring a functional film, and in reproducibility and stability during storage, and a method for its production. Also, the invention provides a functional film containing a melanin and its method for production. Specifically, it provides a functional film containing a melanin of which the alteration is improved and which is excellent in the property for protecting eyes from ultraviolet rays, and in its method for production.The method for producing a melanin of the present invention, comprises, at least, under controlled conditions, a step for an oxidative reaction wherein a melanin precursor is continuously oxidized while the mole ratio of the melanin precursor relative to the oxidative agent is maintained at a constant ratio, and a step for precipitation wherein a melanin is precipitated by acidifying a reaction solution after the step for an oxidative reaction.

The invention relates to the field of special cosmetics, in particular to a single-agent-type hair dye. An adopted dyeing agent is prepared from a plant dyeing agent and a melanin precursor. The melanin precursor is prepared from 5,6-dihydroxyindole, 5,6-dihydroxyindole-2-carboxylic acid, 5,6-dihydroxyindoline and 5,6-dihydroxyindoline-2-carboxylic acid. The plant dyeing agent is an extracting solution of gallnuts, mulberries, black sesame, polygonum multiflorum, Chinese herbaceous peonies and lotus roots. According to the prepared composite single-agent-type hair dye, the formula is simple, the raw materials are safe, the stability of the formula is high, and the composite single-agent-type hair dye has the hair caring effect and the hair protection effect, and also has the advantages of being good in hair dyeing effect and high in dyeing performance.

The invention discloses a preparation method of an all-natural enzyme fermented black hair dye, which comprises the following steps: the step 1, preparing tyrosinase solution by black soybean; the step 2, preparing a tyramine substrate solution; the step 3, preparing melanin precursor in a biological fermentation system; and the step 4, adding auxiliary agent and mordant into the melanin precursorprepared in step 3 to prepare a hair dye. The invention utilizes pure natural black soybean and food-grade tyramine as raw materials, adopts green biological fermentation method, and successfully prepares all-natural black hair dye with black dyeing effect. The invention effectively overcomes the use of ammonia water, hydrogen peroxide, p-phenylenediamine and its derivatives in the chemically synthesized hair dye, which are harmful to human body. The invention overcomes the difficulty of extracting pigment from natural hair dye and is suitable for large-scale popularization in the market.

The invention provides a method for preparing melanin and precursors thereof by utilizing a complex enzyme. The method comprises the following steps: utilizing the complex enzyme containing tyrosinase, which is extracted from bacillus fermentation liquid producing the melanin, taking tyrosine and / or a derivative thereof as a substrate, and generating the melanin and the precursors thereof by enzymatic reaction. The complex enzyme used by the method is stable in source, high in enzyme activity and high in production efficiency; the production of a series of the melanin precursors through the enzymatic reaction method is simple, convenient and easy to operate, the enzyme can be further used repeatedly through a carrier immobilization method, the cost is further reduced, the production efficiency is improved, and the prepared melanin precursors can be used as effective hair dyes and antioxidants.

The invention discloses a preparation method of melanin particles. The method comprises the following steps: (1) adding an alkali into a water solution containing a melanin precursor, and adjusting the pH value to be 7-13; (2) adding an oxidizing agent into the system, carrying out heating and stirring to carry out an oxidation reaction on the melanin precursor, and simultaneously promoting a self-polymerization reaction; and (3) ending the reaction, adjusting the pH value of the system to be less than or equal to 7, and carrying out centrifugal drying. The melanin precursor used in the preparation method is low in price, each of the prepared melanin particles is of an obvious spherical shape, and the particle size is uniform. A polymer composite material obtained by compounding the prepared melanin particles with polycarbonate and the like has excellent ultraviolet blocking capability and high cost performance.

An air-oxidative type hair dye composition containing a melanin precursor prepared by a process including (A) an oxidation step for converting, into the melanin precursor, a tyrosine or derivative thereof used as a starting substance with an enzyme or cell that is derived from a fungus selected from the group consisting of fungi belonging to the genera Aspergillus, Neurospora, Rhizomucor, Trichoderma, and Penicillium and that exhibits a catechol oxidase activity.

The invention belongs to the field of special cosmetics, and particularly relates to a preparing method for single-agent hair dye and a hair dyeing method. The preparing method for the single-agent hair dye includes the following steps that certain amount of deionized water is weighed and heated to 70-80 DEG C, lipid is added, and after the lipid is completely dissolved, a surfactant is added and mechanically stirred for 20-30 min; the temperature is lowered to 40-55 DEG C, an antioxidant, a chelating agent and an alkaline agent are sequentially added and stirred for 20-30 min, and hydrogen peroxide and organic solvent are added and stirred for 2-5 min; a melanin precursor is added and stirred for 10-15 min, and a mordant is added and stirred for 5-10 min; the stirring speed is increased, a thickening agent is added, and stirring is carried out for 20-30 min after water is supplemented to the system to obtain the single-agent hair dye. The preparing process is simple and easy to operate, the prepared single-agent hair dye is high in stability and capable of being stored for 6 months in a sealed mode at the normal temperature, the hair dyeing time is shorter, and the hair dyeing temperature is low.

The invention relates to the technical field of sterilization of hair dyeing products prepared from melanin precursors, and particularly discloses a preparation method and application of a hair dyeing product containing a melanin precursor prepared through biological fermentation. The method specifically comprises the steps: (1) extracting an edible mushroom compound enzyme solution, and performing fermentation conversion and concentration to obtain a concentrated solution containing a melanin precursor substance; (2) carrying out sectional high-temperature sterilization on the concentrated solution at the temperature of 90 DEG C-95 DEG C for 30-40 minutes, standing for 14-16 hours after sterilization, and then carrying out sterilization at the same temperature and for the same time as those of the first-time sterilization; and (3) detecting that hair is completely sterile through microorganism detection, and adding a coloring agent auxiliary material to prepare a hair dyeing product. Product microorganisms can be effectively killed, melanin precursor substances and effective nutritional ingredients can be reserved to the maximum extent, the whole process is simple and easy to implement, special high-pressure and high-temperature equipment is not needed, and industrial popularization is facilitated.

The invention discloses whitening skin-care facial mask paste and a preparation method thereof. The whitening skin-care facial mask paste comprises, by weight, 0.1%-10% of neohesperidin dihydrochalcone, 0.1%-10% of baicalin, 0.1%-5% of Daidai fruit gum, 0.1%-2% of Daidai essential oil, 10%-20% of an organic solvent, 10%-15% of kaolin, 5%-10% of bentonite, 1%-5% of Tween 80 and the balance of water. Through combination of neohesperidin dihydrochalcone and baicalin according to the above weight ratio, the active site of tyrosinase can be destroyed and the tyrosinase does not act the melanin precursor tyrosine so that the formation of melanin is inhibited. The neohesperidin dihydrochalcone and baicalin can effectively inhibit the up-regulation of the MMP-1 gene caused by infrared rays, thereby effectively preventing premature aging of the human skin. The preparation method of the whitening skin-care facial mask paste utilizes easily available raw materials, realizes a low cost, has simpleprocesses and realizes industrial production.

A keratin fiber dyeing composition and method comprising a composition A comprising a melanin precursor, such as 5, 6-dihydroxyindole or 5, 6-dihydroxyindoline, and a composition B comprising a salt of a transition metal ion, such as a bivalent copper ion, a bivalent manganese ion, a bivalent iron ion, and a chloride ion and TRIS. The two compositions are used successively, and a cleaning process can be performed between the composition A and the composition B. According to the composition and the hair dyeing method, the coloring time is short, and the color is closer to the natural hair color of a black hair variety.

The invention discloses a double-agent melanin precursor hair dye and a three-agent melanin precursor hair dye. The double-agent melanin precursor hair dye comprises an agent A and an agent B; the three-agent melanin precursor hair dye comprises an agent A, an agent B and an agent C; the agent A and the agent C both comprises melanin precursors, common hair dye auxiliaries and water; the common hair dye auxiliaries refer to one or more of a wetting agent, a thickening agent, a surfactant, a moisturizing agent and a pH value regulating agent. By combination of advantages of chemical synthesized hair dye and natural hair dye, compound enzyme liquor in natural edible fungi is extracted, amino acids are subjected to bioconversion to synthesize melanin precursor substances such as hallachrome, 5,6-dyhydroxyindole and 5,6-dyhydroxyindole-2-carboxylic acid, skin irritation and allergization are avoided, high safety is achieved, and natural black hair dyeing effects are kept. In addition, due to various agent type choices, the multi-agent melanin precursor hair dye has a great popularization and application value in the field of hair dye preparation.

The invention discloses a melanin precursor substance hair dye. The melanin precursor substance hair dye consists of a melanin precursor, a common hair dye adjuvant and water, wherein the melanin precursor includes dopachrome, 5,6-dihydroxyindole and 5,6-dihydroxyindole-2-carboxylic acid; the melanin precursor accounts for 0.01-5% of the hair dye in percentage by weight; and the common hair dye adjuvant includes one or more of a wetting penetrating agent, a thickening agent, a surfactant, a moisturizer and a pH value regulating agent. The hair dye disclosed by the invention combines the advantages of a chemically synthetic hair dye and a natural hair dye; by extracting complex enzyme liquid in natural edible fungi, such melanin precursor substances as the dopachrome, the 5,6-dihydroxyindole, the 5,6-dihydroxyindole-2-carboxylic acid and the like are synthesized through bio-conversion by virtue of amino acid, so that the hair dye is free from irritation and allergy to skin, high in safety and capable of keeping a natural black hair dyeing effect; and the hair dye has huge popularization and application values in the field of the preparation of hair dyes.

The invention discloses a whitening and skin care essence solution and a preparation method thereof. The essence solution is prepared from, by weight, 0.1-10% of neohesperidin dihydrochalcone, 0.1-10%of baicalin, 0.1-5% of citrus aurantium pectin, 0.1-2% of citrus aurantium essential oil, 10-20% of organic solvent and the balance water. Among the components of the whitening and skin care essencesolution, neohesperidin dihydrochalcone and baicalin are compounded according to the weight percentages above, the active parts of tyrosinase can be destroyed, the tyrosinase loses the function on melanin precursor tyrosine, and therefore the purpose of inhibiting the formation of melanin is achieved. In addition, neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, and therefore the premature senility of the skin of the human body can be effectively prevented. The preparation method of the whitening and skin care essence solutionhas the advantages that the raw materials are easy to obtain, the cost is low, the method is simple, and the industrialized production is easily achieved.

The invention discloses a whitening and skin care lotion and a preparation method thereof. The lotion is prepared from, by weight, 0.1-10% of neohesperidin dihydrochalcone, 0.1-10% of baicalin, 0.1-5%of citrus aurantium pectin, 0.1-2% of citrus aurantium essential oil, 10-20% of organic solvent, 0.01%-0.1% of carbomer and the balance water. Among the components of the whitening and skin care lotion, neohesperidin dihydrochalcone and baicalin are compounded according to the weight percentages above, the active parts of tyrosinase can be destroyed, the tyrosinase loses the function on melanin precursor tyrosine, and therefore the purpose of inhibiting the formation of melanin is achieved. In addition, neohesperidin dihydrochalcone and baicalin can effectively inhibit MMP-1 gene up-regulation caused by infrared rays, and therefore the premature senility of the skin of the human body can be effectively prevented. The preparation method of the whitening and skin care lotion has the advantages that the raw materials are easy to obtain, the cost is low, the method is simple, and the industrialized production is easily achieved.

A solid-state battery is provided. The battery includes a melanin structure formed of at least one melanin material embedded in an inert material, and first and second metal bands which serve as first and second electrodes, respectively. The melanin material is selected from the group consisting of melanin, melanin precursors, melanin derivatives, melanin analogs and melanin variants. The solid-state battery does not need to be recharged or reloaded.

Electrochemical processes and systems for preserving perishable food are described. The process and system allow for the preservation of perishable food in the presence of water moisture, melanin, or a precursor, derivative, analog, or variant of melanin, and electromagnetic energy, such as visible or invisible light energy. There exists a need in the art for improved methods and processes for preserving perishable foods that overcome certain disadvantages associated with known methods for preserving perishable food, such as addition of preservatives, refrigeration / freezing, drying / dehydration of food, and storage under vacuum. The invention satisfies this need by providing a process and system for preserving perishable food in the presence of water moisture, electromagnetic energy, and melanin, melanin precursors, melanin derivatives, melanin analogs, or melanin variants.

The invention discloses a method for preparing an all-natural enzyme-fermented black hair dye. The steps are as follows: step 1, prepare tyrosinase liquid by using black soybeans; step 2, prepare tyramine substrate solution; step 3, prepare a biological fermentation system The melanin precursor; step 4, adding auxiliary agent and mordant to the melanin precursor prepared in step 3 to make a hair dye. The invention utilizes pure natural black soybeans and food-grade tyramine as raw materials, adopts a green biological fermentation method, and successfully prepares an all-natural black hair dye with blackening effect. It effectively overcomes the use of chemically synthesized hair dyes containing ammonia, hydrogen peroxide, p-phenylenediamine and its derivatives, which are harmful to the human body; overcomes the problem of difficult extraction of pigments in natural hair dyes, and is suitable for large-scale use in the market Scope promotion.

A safe and non-toxic dyeing and ironing agent, a preparation method and an application thereof belong to the field of special cosmetics. The ironing agent is a melanin dyeing and ironing agent that combines dyeing and ironing, and includes agent A1, agent A2, agent B and agent C. Among them, agent A1 is thioglycolic acid, thioglycolate salts or cysteine ​​reducing agent solution; agent A2 includes cystine or its derivatives, buffer solution and melanin precursor; agent B is sodium bromate or hydrogen peroxide Type oxidant solution; C agent includes melanin precursor substance, buffer solution and oxidant. The present invention uses melanin precursor substances for hair dyeing, and avoids the use of phenylenediamine substances with high carcinogenic and sensitizing risks. The invention combines the hair dyeing process with the perm process, realizes the integration of dyeing and perming, and does not need to perm first and then dye the hair twice to damage the hair. The invention uses melanin to adhere to the hair surface, and the melanin has good ultraviolet shielding effect, can protect hair keratin from yellowing and becoming brittle by ultraviolet rays, and protect damaged hair.

To provide: a melanin which has the excellent property of dyeing a functional film and is excellent in reproducibility and storage stability; a process for producing the melanin; a functional film which contains the melanin, is reduced in melanin fluctuation, and has the excellent ability to protect the eyes from ultraviolet; and a process for producing the film. The process for melanin production comprises: an oxidation reaction step in which a melanin precursor is continuously oxidized with an oxidizing agent in an aqueous alkali solution while the molar ratio of the melanin precursor to the oxidizing agent is kept constant; and a precipitation step in which the liquid reaction mixture after the oxidation step is acidified to precipitate a melanin. The process for producing the melanin-containing functional film comprises: a step in which a film is treated with an aqueous alkali solution containing at least the melanin; and a step in which the film treated with the aqueous alkali solution is treated with an aqueous solution containing an inorganic salt.