The invention discloses hot and spicy seafood sauce. The hot and spicy seafood sauce is prepared from the following raw materials: dried small shrimps, mussels, squid meat, minced garlic, minced ginger, chopped onions, mustard, Chinese prickly ash powder, hot pepper oil, table salt, cooking wind, edible oil, white sugar, orange juice, peanut butter, Qi-county broad bean paste, maltodextrin, xanthan gum, potassium sorbate, soybean polysaccharide and an oil-water stabilizing agent. The hot and spicy seafood sauce disclosed by the invention is mellow in flavor, delicious and palatable in taste, fine and smooth in sauce texture, hot and spicy in taste, semi-fluidic in organizational form, uniform in shape and good in stability; and the hot and spicy seafood sauce is not liable to precipitate and stratify for a long time. The invention further discloses a processing technology of the hot and spicy seafood sauce; and the processing technology is simple in processing steps, strong in operability, low in equipment requirements and suitable for industrialized production.