16 results about "Taste Bud Cells" patented technology

The invention discloses a fluorescent array sensing system based on bionic taste sense, a construction method of the fluorescent array sensing system and application of the fluorescent array sensing system in food safety intelligent detection. According to the system, a functionalized ultrathin Ti3C2 MXene nanosheet serves as a bionic tongue carrier, multicolor silver nanoclusters synthesized by oligonucleotide chains are adsorbed on the surface of the functionalized ultrathin Ti3C2 MXene nanosheet to serve as bionic taste bud cells, different DNA chains can form different fluorescence emissions, the characteristic that fluorescence can be designed is achieved, and the preparation process of signal molecules can be greatly simplified. When a plurality of hazardous substances are added into the sensing array at the same time, the Ti3C2 MXene with strong binding capacity can preferentially capture a target object, and the silver nanoclusters with weak binding capacity can release or adsorb, so that fluorescence signals with different colors are changed, and a characteristic fingerprint spectrum is formed. And in combination with a machine learning algorithm, rapid, accurate, qualitative and quantitative intelligent identification of multiple food hazardous substances can be realized at the same time, and a new strategy is provided for simultaneous detection of multiple hazardous substances in food safety.

The invention discloses a nutritional composition capable of regulating appetite and body weight of people after chemotherapy and improving taste perception capability and application thereof. The nutritional composition provided by the invention contains milk powder, soybean protein, concentrated whey protein, bovine colostrum powder, hydrolyzed yolk, a red bean extract, a Chinese date extract, lily freeze-dried powder, broccoli freeze-dried powder, a radish seed extract, a peach kernel extract, xanthan gum and Arabic gum. The food can obviously increase appetite of people after chemotherapy and restore weight, and is helpful for treating or improving symptoms such as inappetence, weight loss and weakness of chemotherapy patients. When being applied to paclitaxel (PTX)-induced taste disorder model animals, the paclitaxel protein can improve the taste perception capability, increase the cross sectional area of a taste bud, remarkably repair taste structural damage, reduce the level of proinflammatory factors in serum and relieve hepatotoxicity caused by a chemotherapeutic drug PTX; and moreover, the water solubility and the stability are better, adhesion and layering are avoided, and stable storage is facilitated.

Smell loss (hyposmia) is a common cognitive deficit perceived clinically as a nasal abnormality but, in reality, it is a deficit of complex biochemical detection and processing of externally generated chemical events. A major mechanism initiating hyposmia involves abnormalities of growth of human olfactory cells through altered growth factor stimulation of stem cell activity. While several growth factors are involved well known signaling substances generate and perpetuate this process; among these substances are cAMP and cGMP. We have hypothesized a role for cAMP in taste and olfaction as a growth factor necessary for stem cell maturation. We have thus measured cAMP and cGMP in parotid saliva of 19 normal subjects and 144 patients with hyposmia to evaluate roles for these signals in cognition. Results indicate that patients secrete significantly less cAMP (0.40+ / −0.03 pmol / mg protein (Mean+ / −SEM); patients; 0.67+ / −0.09, normals, p<0.005) and significantly less cGMP (0.072+ / −0.003, patients; 0.100+ / −0.007, normals, p<0.005) than do normals. While parotid gland secretions relate directly to taste bud growth factors many substances secreted in saliva are similar to those secreted in nasal mucus. The present results indicate aberrant signaling in saliva may serve both as a marker for hyposmia and as an indicator of a mechanism which interferes with olfactory system function.

The invention relates to the technical field of rehabilitation medical instruments, in particular to a pain relieving and thirst quenching buccal structure used after general anesthesia. Comprising a base, a supporting module, a shell, a controller, a cable, a fixing base, a supporting frame, a refrigeration piece, a temperature conduction rod, a mouthpiece, a cooling head, a rail, a sliding block and an adjusting module, the controller is arranged in the shell, the two ends of the cable are connected with the controller and the refrigeration piece correspondingly, the supporting frame is slidably arranged in a containing groove, and the refrigeration piece is fixedly connected with the supporting frame; the two ends of the temperature conduction rod are connected with the refrigeration piece and the mouthpiece respectively, the cooling head is fixedly connected with the mouthpiece, the rail is fixedly connected with the fixing base, the sliding block is fixedly connected with the supporting frame and located on the outer side wall of the supporting frame, the sliding block is arranged in the rail in a sliding mode, and the adjusting module is connected with the supporting frame. The effects of being convenient for operation patients with different tooth conditions to use after the general anesthesia operation and being beneficial to stimulating taste buds of the operation patients to secrete saliva are achieved.

The present disclosure relates to a mouthpiece (200) for an aerosol generating device, an aerosol generating device (300) comprising such a mouthpiece, a method for electrically stimulating a user's taste buds, and a method of manufacturing a mouthpiece for an aerosol generating device. The mouthpiece includes an air flow channel (230) that extends at least partially through the mouthpiece to a mouthpiece opening disposed at a proximal end of the mouthpiece. The mouthpiece includes a first electrode (240) disposed on a front surface of the mouthpiece at the mouthpiece opening to provide a first electrical contact to a user. The mouthpiece includes a second electrode (220) disposed on a lateral surface of the mouthpiece to provide a second electrical contact to a user.

The application discloses a cigarette smoke sweet feeling enhancement method based on aroma synergy, which comprises the following steps: preparing a sweet feeling enhancement base: dissolving or dispersing an aroma composition composed of milk flavor, caramel sweet flavor and fruit sweet flavor in a solvent to form a sweet feeling enhancement base; applying the sweet feeling enhancement base: applying the prepared sweet feeling enhancement base to cigarette material to obtain cigarette material treated by the sweet feeling enhancement base; subsequent treatment: balancing the cigarette material treated by the sweet feeling enhancement base and rolling the cigarette material into cigarettes. The cigarette smoke sweet feeling enhancement method based on aroma synergy does not directly act on taste buds, but adds specific aroma combinations that can effectively induce and enhance sweet feeling perception, utilizes the cross-modal interaction of olfaction-taste, and forms a stronger and more natural sweet feeling experience in the brain of consumers; the method does not directly stimulate taste buds, and fundamentally avoids the after-bitterness and metallic taste possibly caused by excessive sweeteners.

The invention discloses pea protein-Arabic gum salt-loaded particles based on Maillard reaction and a preparation method thereof, and belongs to the technical field of food processing. According to the pea protein-Arabic gum salt-carrying particles based on the Maillard reaction and the spray drying mode and the preparation method thereof, the Maillard reaction is combined with the spray drying technology, protein-polysaccharide is subjected to controllable covalent coupling, a compact network structure is constructed, and therefore the slow-release performance of salt is changed, and the salt-carrying capacity of the pea protein-Arabic gum salt-carrying particles is improved. Sodium ions are promoted to reach taste buds in the oral cavity and then are locally released at high concentration, so that the salty taste perception is remarkably improved.

The utility model provides an adjustable bionic tongue sleeve type suction tube, which belongs to the technical field of suction tubes and comprises a bionic tongue sleeve. Comprising a silica gel base body, a plurality of main flow channels formed in the upper layer of the tongue face part of the silica gel base body, a main flow dividing groove formed in the silica gel base body and communicated with the confluence ends of the main flow channels, a flow dividing cavity formed in the lower layer of the tongue face part of the silica gel base body, and a plurality of auxiliary flow dividing grooves formed in the bottom of an inner cavity of the flow dividing cavity. The main channel and the auxiliary channel operate independently, the taste bud area is covered in a directional mode through the micro-flow through holes of the auxiliary channel, the main channel avoids the sensitive area, liquid mixing is effectively prevented, meanwhile, the drinking taste is improved through trace flavor liquid, and the drinking desire is stimulated; by means of the more than eight main flow channels distributed in the radial shape and the detachable channel plugs, a user can freely block part of the channels, the liquid flowing path and flow distribution are dynamically changed, and the comfort experience of the user can be improved.

The present invention provides an application of a mouse taste bud tissue biosensor in screening TRPM8 antagonists. The mouse taste bud tissue biosensor is constructed by using a screen-printed electrode as a detection device and a mouse taste bud tissue membrane as an identification element. The tissue biosensor method has high sensitivity, strong specificity, small sample volume, and a detection concentration as low as 10 ‑ 22 mol·L ‑1 The invention also achieved the screening of TRPM8 receptor antagonists from candidate natural compounds in traditional Chinese medicine by analogy with enzymatic reaction kinetics. This invention forms a set of methods for screening TRPM8 receptor antagonists based on mouse taste bud tissue sensors.

The coffee tasting cup comprises a cup belly used for containing coffee, the upper end of the cup belly is gradually closed inwards to form a cup neck, the peripheral side of the cup neck extends outwards to form a cup opening, the caliber of the cup belly is larger than that of the cup opening, the caliber of the cup opening is larger than that of the cup neck, and a cavity is defined by the cup neck and the cup opening jointly. The inner side wall of the cavity is divided into a first flavor side wall and a second flavor side wall in the longitudinal direction, and the thickness of the first flavor side wall is larger than that of the second flavor side wall. According to the coffee tasting cup, more coffee liquid poured out through the second flavor side wall makes contact with the tongue tip area, and therefore when coffee flowing through the second flavor side wall is tasting, the coffee flavor is fuller, and the taste is richer. When coffee liquid is poured out through the first flavor side wall, taste buds can more directly capture the sour and sweet taste of coffee, and the acid quality is brighter. Therefore, according to the coffee tasting cup, double sensory experiences can be obtained only through one cup.

The straw comprises a drinking water straw body and a medicine straw body, the head of the drinking water straw body is connected with the head of the medicine straw body through a suction nozzle connector, the tail of the drinking water straw body is separated from the tail of the medicine straw body, and an assembling opening is formed in the suction nozzle connector and used for assembling the medicine straw body. An outer frame pipe is arranged at the side end of the suction nozzle connector, and the assembling opening is located in the edge of the suction nozzle connector. According to the straw, liquid medicine and drinking water can be temporarily mixed, bitter taste of the liquid medicine is reduced due to dilution, meanwhile, the total flow of the drinking water straw is larger, and the assembly opening is located at the edge of the suction nozzle connector and is arranged above a taste bud in an oral cavity when the straw is used, so that the taste of the drinking water straw is improved. Therefore, a large amount of drinking water forms a layer of water film on the taste bud, the liquid medicine quickly passes through the water film through suction force generated by the oral cavity, the contact area and the residence time of the liquid medicine and the taste bud are remarkably reduced, and the bitter taste of the liquid medicine is greatly reduced.

The invention discloses a fragrance-imitating green plum flavor essence which is prepared by adopting a full-formula form, and natural green plum pulp does not need to be adopted, so that the problems of instability of different batches and precipitation of products are solved. The fragrance-imitating green plum flavor essence can be used for fragrant tea, various drinks and soft drinks, so that the pursuit of vast consumers for taste buds is met.

The invention relates to the technical field of traditional Chinese medicine compositions for children eczema, and discloses a traditional Chinese medicine composition for treating children eczema, which comprises 4-10 parts of cape jasmine flower, 6-11 parts of turmeric, 4-9 parts of borneol, 4-14 parts of alum, 15-30 parts of dark plum, 7-14 parts of red sage root, 8-20 parts of purslane, 4-9 parts of purified water and 3-6 parts of glycerin. The preparation method of the traditional Chinese medicine composition comprises the following steps: step 1, simultaneously putting the same amount of gardenia, turmeric, borneol, alum, dark plum, salvia miltiorrhiza and purslane into crushing equipment, mixing and crushing; according to the traditional Chinese medicine composition for treating children eczema, through the brand-new prepared traditional Chinese medicine composition, the traditional Chinese medicine composition is more excellent in infant eczema treatment, taste bud stimulation and oral administration harm are avoided, and the problems that existing medicines used for treating children eczema are large in taste irritation, are not suitable for infants when being orally taken, and are not suitable for children are solved. Therefore, the infant eczema treatment is influenced.

A taste bud emulator system comprising a plurality of circuits configured to interact with a sample and generate a plurality of output signals indicative of cellular responses of a taste bud cell to the sample. The plurality of output signals can comprise: an axon output signal indicative of an axonal output of a taste bud cell in response to interaction with the sample; a cell output signal indicative of a cell membrane voltage of a taste bud cell in response to interaction with the sample; and state space output signal indicative of a state of one or more cell membrane proteins of a taste bud cell in response to interaction with the sample.

The application provides a slow-release edible salt and a preparation method thereof, and the slow-release edible salt comprises salt particles and a slow-release layer wrapped on the surface of the salt particles; the slow-release layer is prepared from the following raw materials in parts by weight: 100 parts of water, 3-10 parts of an emulsifier, 0.5-3 parts of sodium citrate, 4-10 parts of glutamine peptide, 0.5-1.0 parts of water-soluble soybean polysaccharide and 0.01-0.05 parts of tea polyphenol; the slow-release edible salt provided by the application is wrapped with a slow-release layer on the surface of the salt particles, so that the release area of the salt is reduced, the release speed of the salt is reduced, the release of the salt is retarded, and the slow-release effect of the salt is ensured; meanwhile, the glutamine peptide in the slow-release edible salt provided by the application can enhance the perception of salty taste by human taste buds, so that the intake of the edible salt is reduced.

The invention relates to a multifunctional oral cavity exerciser for a head and neck radiotherapy patient and a control method, and relates to the technical field of medical instruments. Comprising an exerciser body. A containing groove is formed in the exerciser body; a freezing channel is arranged in the exerciser body and is used for introducing freezing gas. Irritant liquid is poured into the containing groove, then the exerciser body is placed into the oral cavity of a patient, and the tongue of the patient can be bounced so that tongue exercise can be conducted; in the tongue popping process of a patient, the irritant liquid in the containing groove can drop to the tongue below, and the effect of stimulating taste buds is achieved. Meanwhile, freezing gas can be introduced into the freezing channel, the freezing gas can refrigerate and cool the exerciser body, and the effect of stimulating the tongue of the patient is achieved through cold therapy. According to the invention, oral complications can be prevented and recovered, pains of radiotherapy patients are relieved, and the problem that existing medical instruments have a single treatment function for oral complications generated after radiotherapy is solved.