The invention discloses an LED drive circuit with output current self-adjustment capability, which comprises a single-phase AC input power supply, a rectifier bridge, a first power switch tube, a second power switch tube, a first power diode, a second power diode, a second power switch tube, and a second power switch tube. An inductor, a first capacitor, a second capacitor, a high-frequency transformer, a first current sampling resistor, a second current sampling resistor, a first voltage sampling resistor, a second voltage sampling resistor, a third voltage sampling resistor, and a fourth voltage sampling resistor , snubber resistor, snubber capacitor, snubber diode, active power factor correction module. The invention proposes a solution to solve the problem that LEDs work in the state of over-rated current for a long time due to the disconnection of parallel branch circuits. With the characteristics of high stability and safety, it is suitable for the control of various LED lighting circuits.