32results about How to "Avoid localization" patented technology

The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and/or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

An audio signal processing circuit for an audio reproduction apparatus at least having sound source located substantially at left and right sides to a listener, is provided. The audio signal processing circuit includes a phase difference control portion. The phase difference control portion receives a left channel signal for the left sound source and a right channel signal for the right sound source, controls a phase difference between the left and right channel signals so as to produce a relative phase difference in the range of 140 degrees to 160 degrees, and outputs the phase difference controlled left and right channel signals for the left and right sound source, respectively.

A hydrogen storage device prevents localization of hydrogen occlusion alloy and ensures rapid discharge of hydrogen. The hydrogen storage device has a plurality of porous molded pieces arranged longitudinally at predetermined intervals. Conductive cushioning materials are inserted between the molded pieces and between the molded pieces and an adiabatic insulation material. The conductive cushioning materials include first conductive cushioning materials inserted between the adiabatic insulation material and upper and lower end surfaces of the molded pieces and second conductive cushioning materials inserted between left and right end surfaces of the adiabatic insulation material. Disposed at opposed ends of a row of the molded pieces are movable urging electrodes which can move in response to dimensional changes of the molded pieces resulting from their volume changes and which urge the molded pieces to constantly maintain physical contact between the molded pieces and lids.

In accordance with this invention, a molecular probe for detection of a nucleic acid target containing a preselected target sequence is constructed and has at least two sources of a signal: a conventional reporter source and a reference source in a form of a luminescent material, e.g., a fluorophore, quantum dot, fluorescent nanoparticle, or other fluorescent reference dye/nanoparticle/microparticle conjugated to the molecular probe.

An ion pump and a charged particle beam device each includes two opposite flat-plate cathodes, an anode with a cylindrical shape having openings that face the respective flat-plate cathodes, a voltage application unit configured to apply a potential higher than potentials of the flat-plate cathodes to the anode, a magnetic field application unit configured to apply a magnetic field along an axial direction of the cylindrical shape of the anode, and a cathode bar arranged within the anode. The surface of the cathode bar is formed with a material that forms a non-evaporative getter alloy film on the anode or the flat-plate cathodes.

Provided is a wireless positioning method using a wireless sensor network, for estimating a position of an unknown node that is a positioning target by using a plurality of anchor nodes arranged at regular intervals, the wireless positioning method including: setting a plurality of test nodes at regular intervals on a space formed by some of the plurality of anchor nodes; obtaining a number and position information of anchor nodes within a predetermined distance from the unknown node; detecting at least one test node matching the obtained number and position information; and estimating a position of the unknown node by calculating an average coordinate value of the detected at least one test node.

Compounds of the formula: RC(O)O-spacer-OC(O)R′, wherein (i) RC(O)— is the acyl residue of an NSAID or other pharmaceutically active agent bearing a carboxylic acid function, (ii) spacer is C_n alkyl, (iii) n is from 1 to 6, and (iv) R′ is substituted or unsubstituted heteroaryl or heterocycle, and pharmaceutical compositions thereof.

A semiconductor device has a semiconductor substrate of a first conductivity type, a first well region of the first conductivity type which is formed to extend from the surface of the semiconductor substrate toward the inside thereof, a pair of second well regions of a second conductivity which are formed to extend from the surface of the semiconductor substrate toward the inside thereof in such as manner as to sandwich the first well region therebetween, and a third well region of the second conductivity type which is formed under each of the first well region and the pair of second well regions in the semiconductor substrate. The third well region electrically connects the pair of second well regions to each other. The first well region has at least a portion thereof connected to the region of the semiconductor substrate in which the third well region is not formed.

This application relates to potent oligonucleotides useful for reducing HBsAg expression and treating HBV infections.

Disclosed herein are novel derivatives of fendiline, including compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives, for example, for the inhibition of K-Ras plasma membrane localization, and compositions thereof, including for the treatment of cancer, are also provided.

The present invention relates to a method to protect, in a secured container using an encryption key, a set of mixed sensitive and public data to be transferred to an entity. The method includes the steps of: generating a random key, ciphering the set of mixed sensitive and public data using said random key to obtain a ciphered set of data, generating an initialization value, and defining configuration information for the secured container. The initialization value, the configuration information and random key form a preamble. The preamble and the ciphered set of data are encrypted. The initialization value renders the resulting encrypted data variable from a secured container to another even in case of repetitive configuration information in the preamble.

A 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically acceptable salt thereof, process for its preparation, its pharmaceutical composition and method for the treatment for stalling vitiligo spread or provide prophylactic benefit to individuals with vitiligo predisposition.

Provided is an acoustic transducer which is used by being fitted into an ear of a listener, is formed in a compact and lightweight shape, and preferably prevents re-reflection of a sound wave. An acoustic transducer 100 is formed of a film-shaped material having an expanding and contracting action and includes a cylindrical acoustic transducing element 101. The cylindrical acoustic transducing element 101 also functions as a sound guide tube. The acoustic transducing element 101 prevents re-reflection of the sound wave reflected by an eardrum when the sound wave has been generated and prevents localization phenomenon and a feeling of pressure in auditory sense. Also, since the acoustic transducing element 101 is formed in a compact and lightweight shape, the acoustic transducing element 101 generates the sound wave for directly reaching the eardrum or collects the sound at a place near the eardrum without a feeling of foreign materials in a case where a person wears the acoustic transducing element 101 the an ear.