33results about How to "Avoid localization" patented technology

The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and / or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

An audio signal processing circuit for an audio reproduction apparatus at least having sound source located substantially at left and right sides to a listener, is provided. The audio signal processing circuit includes a phase difference control portion. The phase difference control portion receives a left channel signal for the left sound source and a right channel signal for the right sound source, controls a phase difference between the left and right channel signals so as to produce a relative phase difference in the range of 140 degrees to 160 degrees, and outputs the phase difference controlled left and right channel signals for the left and right sound source, respectively.

A hydrogen storage device prevents localization of hydrogen occlusion alloy and ensures rapid discharge of hydrogen. The hydrogen storage device has a plurality of porous molded pieces arranged longitudinally at predetermined intervals. Conductive cushioning materials are inserted between the molded pieces and between the molded pieces and an adiabatic insulation material. The conductive cushioning materials include first conductive cushioning materials inserted between the adiabatic insulation material and upper and lower end surfaces of the molded pieces and second conductive cushioning materials inserted between left and right end surfaces of the adiabatic insulation material. Disposed at opposed ends of a row of the molded pieces are movable urging electrodes which can move in response to dimensional changes of the molded pieces resulting from their volume changes and which urge the molded pieces to constantly maintain physical contact between the molded pieces and lids.

An audio signal processing circuit for an audio reproduction apparatus at least having sound source located substantially at left and right sides to a listener, is provided. The audio signal processing circuit includes a phase difference control portion. The phase difference control portion receives a left channel signal for the left sound source and a right channel signal for the right sound source, controls a phase difference between the left and right channel signals so as to produce a relative phase difference in the range of 140 degrees to 160 degrees, and outputs the phase difference controlled left and right channel signals for the left and right sound source, respectively.

In accordance with this invention, a molecular probe for detection of a nucleic acid target containing a preselected target sequence is constructed and has at least two sources of a signal: a conventional reporter source and a reference source in a form of a luminescent material, e.g., a fluorophore, quantum dot, fluorescent nanoparticle, or other fluorescent reference dye / nanoparticle / microparticle conjugated to the molecular probe.

An ion pump and a charged particle beam device each includes two opposite flat-plate cathodes, an anode with a cylindrical shape having openings that face the respective flat-plate cathodes, a voltage application unit configured to apply a potential higher than potentials of the flat-plate cathodes to the anode, a magnetic field application unit configured to apply a magnetic field along an axial direction of the cylindrical shape of the anode, and a cathode bar arranged within the anode. The surface of the cathode bar is formed with a material that forms a non-evaporative getter alloy film on the anode or the flat-plate cathodes.

Provided is a wireless positioning method using a wireless sensor network, for estimating a position of an unknown node that is a positioning target by using a plurality of anchor nodes arranged at regular intervals, the wireless positioning method including: setting a plurality of test nodes at regular intervals on a space formed by some of the plurality of anchor nodes; obtaining a number and position information of anchor nodes within a predetermined distance from the unknown node; detecting at least one test node matching the obtained number and position information; and estimating a position of the unknown node by calculating an average coordinate value of the detected at least one test node.

The present invention provides recombinant microorganisms comprising isobutanol producing metabolic pathway with at least one isobutanol pathway enzyme localized in the cytosol, wherein said recombinant microorganism is selected to produce isobutanol from a carbon source. Methods of using said recombinant microorganisms to produce isobutanol are also provided. In various aspects of the invention, the recombinant microorganisms may comprise a cytosolically active isobutanol pathway enzymes. In some embodiments, the invention provides mutated, modified, and / or chimeric isobutanol pathway enzymes with cytosolic activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Saccharomyces clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.

Compounds of the formula: RC(O)O-spacer-OC(O)R′, wherein (i) RC(O)— is the acyl residue of an NSAID or other pharmaceutically active agent bearing a carboxylic acid function, (ii) spacer is Cn alkyl, (iii) n is from 1 to 6, and (iv) R′ is substituted or unsubstituted heteroaryl or heterocycle, and pharmaceutical compositions thereof.

A sound signal processing apparatus (100) includes: an equalizer (110L) for enhancing an 8 kHz band of a sound signal (#1L); an equalizer (110R) for enhancing an 8 kHz band of a sound signal (#1R); and a filter (120) for delaying a phase of a sound signal (#2L). The filter (120) decreases correlation between the sound signals (#3L) and (#2R). This sufficiently moves a sound image upward, without use of a technique of pseudo surround.

Processes for high speed machining of workpiece materials using high performance tools with prolonged tool life and improved surface finish are provided by vibrating the tool and / or the workpiece at a frequency greater than the frequency of shear localization in the primary shear zone or chip segmentation occurring in the absence of tool vibration, with an amplitude sufficient to break up the tool-chip atomic contact, thereby decreasing the tool-chip contact length through decreasing the tool-chip contact time, thereby suppressing accelerated chemical tool wear caused by dissolution of the tool into the workpiece by nanocrystalline grain boundary diffusion and grain boundary sliding mechanisms by preventing shear localization associated with nanocrystalline grain formation in the primary shear zone of the chip, and suppressing oxidation wear of the tool by preventing segmentation of the chip.

The present disclosure relates to a drive control device and electronic equipment, thereby totally simplifying the control of non-display and display drive terms in each display frame period, which a drive control device performs for the purpose of preventing display lines subjected to the degradation in display performance from being localized, or display lines with flicker arising thereon from being unevenly distributed in adopting the control arranged. Start timing of the display drive term and start timing of the non-display drive term are changed for each display frame period in a first frame mode. A second frame mode has a display drive term, and the display drive term is not interrupted by a non-display drive term halfway. The second frame mode is arranged so that the cycle of the display line clock signal in synchronization with the display line switching cycle is made longer than that in the first frame mode.

A semiconductor device has a semiconductor substrate of a first conductivity type, a first well region of the first conductivity type which is formed to extend from the surface of the semiconductor substrate toward the inside thereof, a pair of second well regions of a second conductivity which are formed to extend from the surface of the semiconductor substrate toward the inside thereof in such as manner as to sandwich the first well region therebetween, and a third well region of the second conductivity type which is formed under each of the first well region and the pair of second well regions in the semiconductor substrate. The third well region electrically connects the pair of second well regions to each other. The first well region has at least a portion thereof connected to the region of the semiconductor substrate in which the third well region is not formed.

Processes for high speed machining of workpiece materials using high performance tools with prolonged tool life and improved surface finish are provided by vibrating the tool and / or the workpiece at a frequency greater than the frequency of shear localization in the primary shear zone or chip segmentation occurring in the absence of tool vibration, with an amplitude sufficient to break up the tool-chip atomic contact, thereby decreasing the tool-chip contact length through decreasing the tool-chip contact time, thereby suppressing accelerated chemical tool wear caused by dissolution of the tool into the workpiece by nanocrystalline grain boundary diffusion and grain boundary sliding mechanisms by preventing shear localization associated with nanocrystalline grain formation in the primary shear zone of the chip, and suppressing oxidation wear of the tool by preventing segmentation of the chip.

A semiconductor device has a semiconductor substrate of a first conductivity type, a first well region of the first conductivity type which is formed to extend from the surface of the semiconductor substrate toward the inside thereof, a pair of second well regions of a second conductivity which are formed to extend from the surface of the semiconductor substrate toward the inside thereof in such as manner as to sandwich the first well region therebetween, and a third well region of the second conductivity type which is formed under each of the first well region and the pair of second well regions in the semiconductor substrate. The third well region electrically connects the pair of second well regions to each other. The first well region has at least a portion thereof connected to the region of the semiconductor substrate in which the third well region is not formed.

A semiconductor device according to the invention includes n-type semiconductor substrate 1; trenches 15 formed in the surface portion of semiconductor substrate 1; a protruding semiconductor region between trenches 15; p-type base layer 2 in the protruding semiconductor region, p-type base layer 2 being positioned as deep as or shallower than trench 15; an n++-type emitter region or a source region in the surface portion of p-type base layer 2; gate insulator film 4a on the first side wall of the protruding semiconductor region; and gate electrode 6 on gate insulator film 4a. Trench 15 is from 0.5 μm to 3.0 μm deep and the short side of trench 15 is 1.0 μm or longer. The short side of the protruding semiconductor region is from 0.5 μm to 3.0 μm long. Gate electrode 6 contains electrically conductive polycrystalline silicon as its main component. Gate electrode 6 is from 0.2 μm to 1.0 μm thick. The semiconductor device according to the invention is manufactured with very low manufacturing costs and with a high throughput of non-defective products. The semiconductor device according to the invention facilitates exhibiting a high IE effects, exhibiting a low ON-state voltage, preventing electric field localization from causing and realizing a high breakdown voltage.

Prenylating enzymes are involved in modifying oncoproteins, such as RAS, so that growth of neoplastic cells becomes uncontrolled. Inactivation of such enzymes can prevent uncontrolled growth. alpha-Dicarbonyl compounds can be used to covalently modify and thereby inactivate prenylating enzymes such as protein farnesyltransferase and protein geranylgeranyltransferase. The compounds can be designed to enhance affinity and / or specificity for a particular protein substrate.

This application relates to potent oligonucleotides useful for reducing HBsAg expression and treating HBV infections.

Disclosed herein are novel derivatives of fendiline, including compounds of the formula: wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising these derivative compounds. Methods and intermediates useful for making the derivatives, and methods of using the derivatives, for example, for the inhibition of K-Ras plasma membrane localization, and compositions thereof, including for the treatment of cancer, are also provided.

Provided is an acoustic transducer which is used by being fitted into an ear of a listener, is formed in a compact and lightweight shape, and preferably prevents re-reflection of a sound wave. An acoustic transducer 100 is formed of a film-shaped material having an expanding and contracting action and includes a cylindrical acoustic transducing element 101. The cylindrical acoustic transducing element 101 also functions as a sound guide tube. The acoustic transducing element 101 prevents re-reflection of the sound wave reflected by an eardrum when the sound wave has been generated and prevents localization phenomenon and a feeling of pressure in auditory sense. Also, since the acoustic transducing element 101 is formed in a compact and lightweight shape, the acoustic transducing element 101 generates the sound wave for directly reaching the eardrum or collects the sound at a place near the eardrum without a feeling of foreign materials in a case where a person wears the acoustic transducing element 101 the an ear.

A method of manufacturing an outer ring member for a constant velocity joint, comprising the steps of forming a secondary molding (20) by applying a preliminary upsetting to a work (10) after applying a forward extrusion-molding (S1) to the work (10) (S2), forming intermediate pre-molded bodies (24, 24a) having annular sloped surfaces (36, 36a) formed thereon to have a difference in flow resistance between large diameter parts (28a to 28c) and small diameter parts (30a to 30c) by applying the upsetting to the upper part (22) of the secondary molding (20) (S3, S3a), forming a quaternary molding (58) having a cup part (62) with track grooves (60a to 60c) by applying a backward extrusion-molding to the intermediate pre-molded bodies (24, 24a)(S4), and applying an ironing to the cup part (62) of the quaternary molding (58) to finish the quaternary molding (58) to product dimensions (S5).

The present invention relates to a method to protect, in a secured container using an encryption key, a set of mixed sensitive and public data to be transferred to an entity. The method includes the steps of: generating a random key, ciphering the set of mixed sensitive and public data using said random key to obtain a ciphered set of data, generating an initialization value, and defining configuration information for the secured container. The initialization value, the configuration information and random key form a preamble. The preamble and the ciphered set of data are encrypted. The initialization value renders the resulting encrypted data variable from a secured container to another even in case of repetitive configuration information in the preamble.

The present invention relates to a method to protect, in a secured container using an encryption key, a set of mixed sensitive and public data to be transferred to an entity. The method includes the steps of: generating a random key, ciphering the set of mixed sensitive and public data using said random key to obtain a ciphered set of data, generating an initialization value, and defining configuration information for the secured container. The initialization value, the configuration information and random key form a preamble. The preamble and the ciphered set of data are encrypted. The initialization value renders the resulting encrypted data variable from a secured container to another even in case of repetitive configuration information in the preamble.

The invention discloses a method for reconfiguring a protocol stack based on an assembly. The method comprises the following steps: simultaneously comparing a protocol assembly of the current protocol stack with the whole of a protocol assembly of the reconfigured protocol stack; confirming that different protocol assemblies exist, and then stopping running the current protocol stack; replacing the protocol assembly of the current protocol stack in the different protocol assemblies with the protocol assembly of the reconfigured protocol stack with same or similar function, and then starting up the running of the protocol assembly of the current protocol stack. The invention also discloses equipment and a system for reconfiguring a protocol stack based on an assembly. The invention can improve the success ratio of reconfiguration and effectively lower the time delay of the reconfiguration.

A 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically acceptable salt thereof, process for its preparation, its pharmaceutical composition and method for the treatment for stalling vitiligo spread or provide prophylactic benefit to individuals with vitiligo predisposition.

A 1,2,3 triazole-thiazole compound of formula (I) or pharmaceutically acceptable salt thereof, process for its preparation, its pharmaceutical composition and method for the treatment for stalling vitiligo spread or provide prophylactic benefit to individuals with vitiligo predisposition.

Provided is an acoustic transducer which is used by being fitted into an ear of a listener, is formed in a compact and lightweight shape, and preferably prevents re-reflection of a sound wave. An acoustic transducer 100 is formed of a film-shaped material having an expanding and contracting action and includes a cylindrical acoustic transducing element 101. The cylindrical acoustic transducing element 101 also functions as a sound guide tube. The acoustic transducing element 101 prevents re-reflection of the sound wave reflected by an eardrum when the sound wave has been generated and prevents localization phenomenon and a feeling of pressure in auditory sense. Also, since the acoustic transducing element 101 is formed in a compact and lightweight shape, the acoustic transducing element 101 generates the sound wave for directly reaching the eardrum or collects the sound at a place near the eardrum without a feeling of foreign materials in a case where a person wears the acoustic transducing element 101 the an ear.