The invention relates to an inclined type pressure regulating valve, a manufacturing method and an application method. The inclined type pressure regulating valve consists of a valve body, a valve spool assembly and a valve bonnet, a valve body upper opening of the upper portion of the valve body is inclined to one end of a water inlet, the valve spool assembly consists of a sealing pressure ring, a pressure spring, an adjusting gland, a pressure regulating driving rod, a spring seat fastening bowl, a positioning nut, a fine-adjustment flexible sealing bowl, a valve spool main body, a valve spool connecting screw rod, a sealing rubber ring, a supporting rod, a gasket, a sealing gasket, a valve top and a locking nut, the valve spool assembly is locked by the positioning nut and the lockingnut via the valve spool connecting screw rod, the upper portion of the valve spool main body is a pressure regulating cavity, the lower portion of the valve spool main body is a flow control cavity, and pressure regulation is realized via the pressure regulating cavity and the flow control cavity. The inclined type pressure regulating valve is scientific in design, reasonable in structure, reliable in performance, low in cost, simple in manufacture and favorable for production, and is impact-resistant, ageing-resistant, non-toxic, corrosion-resistant and antioxidant, components are compact, and automatic adjustment of water pressure is realized by water pressure of a water source. In addition, the inclined type pressure regulating valve is widely applied to agricultural water saving irrigation, is particularly used for slopes and mountainous areas, saves a large quantity of investment, and can also be used for water delivery fields with severe requirements on water pressure.