The invention relates to a turning center with an inverted spindle. The turning center comprises a base plate, a rear chip cleaner, a C-shaped machine tool, a feeding device, a slide plate and a cutter holder, wherein the base plate is fixed on a foundation, the rear chip cleaner longitudinally penetrates the bottom of the base plate in a front-back direction, the C-shaped machine tool is connected to the upper end face of the base plate, the feeding device is biased on one side and longitudinally penetrates the machine tool in a front-back direction, the slide plate is arranged on one side of the machine tool, the slide plate is connected with the machine tool through a linear guide rail, a spindle box is arranged on one side of the slide plate, the slide plate is connected with the spindle box through the linear guide rail, the cutter holder is mounted in front of the lower side of the machine tool and located below the feeding device, an X-axis drive system is mounted behind the slide plate, and a Z-axis drive system is mounted in front of the slide plate. The turning center has the advantages that the turning center is compact in structure, machine tool floor space can be reduced favorably, and the automation level of the machine tool is increased.