The invention discloses a novel liner plate structure used for a large autogenous mill. The novel liner plate structure comprises a feeding end liner plate, a cylinder liner plate, a discharging end liner plate and a filling ring. The feeding end liner plate comprises a feeding end inner ring liner plate body, a feeding end middle ring liner plate body and a feeding end outer ring liner plate body, all of which are sequentially connected. The cylinder liner plate comprises a feeding end cylinder liner plate body, a middle section cylinder liner plate body and a discharging end cylinder liner plate body. The discharging end liner plate comprises a grid plate, an insensate stone window, an external ore pulp elevator, a discharging end middle liner plate body, a middle ore pulp elevator, an inner ring ore pulp elevator, a material discharging device and the like. A flat-head bolt hole is formed in the material discharging device, and an anti-loosening structure is further arranged at the position, corresponding to the flat-head bolt hole, on the material discharging device. The anti-loosening structure comprises a flat-head bolt, an anti-loosening steel bowl, a large gasket, a lock nut, an anti-loosening bolt, an anti-loosening nut and the like. The problems that during running of the mill, ore pulp circular flow scours an end cover, the filling ring falls, the service life of the cylinder liner plate bodies is not equal, discharging cannot be conducted in time through a discharging opening, the flat-head bolt loosens, and insensate stone is not discharged smoothly can be effectively solved.