The invention relates to a method for realizing local oscillator leakage calibration based on slope. The method comprises the steps of randomly selecting an initial point, setting a stepping value and measuring local oscillator leakage. Circulation of an I component and a Q component is carried out in a large step through a first layer of circulation, and a rough interval range where the lowest point of local oscillator leakage power is located is determined; through second-layer circulation, circulation is carried out in a small step mode, and the power lowest point obtained through measurement is recorded; and through a third layer of circulation, dimension value offset is carried out on the I component and the Q component respectively, the value of the lowest point is recorded, and the I component and the Q component with the minimum local oscillator leakage power value are obtained. The invention also relates to a corresponding system, device, processor and computer readable storage medium. According to the method, the system and the device for realizing local oscillator leakage calibration based on the slope, the processor and the computer readable storage medium thereof, compared with I and Q changes of one dimension, the measurement times of local oscillator leakage calibration are greatly reduced, so that the required calibration time is shortened, and the calibration efficiency is higher. According to the invention, after the I component and the Q component are respectively adjusted to the lowest point, the I component and the Q component are respectively adjusted, and the numerical value is changed.