The invention discloses a three-dimensional constant-force parallel flexible micro-positioning platform. The three-dimensional constant-force parallel flexible micro-positioning platform comprises a main frame, a force input mechanism, a force output mechanism, and a constant force mechanism, wherein the force input mechanism, the force output mechanism and the constant force mechanism are arranged in the main frame. The constant force mechanism comprises a parallel plate spring mechanism, an X-direction constant force mechanism, a Y-direction constant force mechanism and a Z-direction constant force mechanism, wherein the X-direction constant force mechanism, the Y-direction constant force mechanism and the Z-direction constant force mechanism are connected with the parallel plate springmechanism and are mutually orthogonal, the X-direction constant force mechanism comprises a first negative stiffness mechanism and a first plate spring flexible structure which are in series connection, the Y-direction constant force mechanism comprises a second negative stiffness mechanism and a second plate spring flexible structure which are in series connection, and the Z-direction constant force mechanism comprises a third negative stiffness mechanism and a third plate spring flexible structure which are in series connection. The parallel structure is adopted for achieving motion decoupling, the positioning platform is provided with three independent freedom degrees in three-dimensional XYZ directions, meanwhile, a flexible hinge is used for connection, traditional connection defectsare overcome, and high-precision positioning is achieved.