51 results about "Fourier transform ion cyclotron resonance" patented technology

An ion separation instrument includes an ion source coupled to at least a first ion mobility spectrometer having an ion outlet coupled to a mass spectrometer. Instrumentation is further included to provide for passage to the mass spectrometer only ions defining a preselected ion mobility range. In one embodiment, the ion mobility spectrometer is provided with electronically controllable inlet and outlet gates, wherein a control circuit is operable to control actuation of the inlet and outlet gates as a function of ion drift time to thereby allow passage therethrough only of ions defining a mobility within the preselected ion mobility range. In another embodiment, an ion trap is disposed between the ion mobility spectrometer and mass spectrometer and is controlled in such a manner so as to collect a plurality of ions defining a mobility within the preselected ion mobility range prior to injection of such ions into the mass spectrometer. In yet another embodiment, an ion inlet of the ion trap may be electronically controlled relative to operation of the ion mobility spectrometer as a function of ion drift time to thereby allow passage therein only of ions defining a mobility within the preselected ion mobility range. The mass spectrometer is preferably a Fourier Transform Ion Cyclotron Resonance mass spectrometer, and the resulting ion separation instrument may further include therein various combinations of ion fragmentation, ion mass filtering, ion trap, charge neutralization and / or mass reaction instrumentation.

The invention relates to an asphalt analysis discriminating method by utilizing an electronic spray ionization Fourier transform ion cyclotron resonance mass spectrometry technology. The asphalt analysis discriminating method comprises the following steps of: (1) detecting a standard sample in an electronic spray ionization Fourier transform ion cyclotron resonance mass spectrometer to determine molecular composition, molecular weight and distributed mass spectrometric data of a polar compound in the standard sample; (2) detecting a sample to be detected in the electronic spray ionization Fourier transform ion cyclotron resonance mass spectrometer to determine the molecular composition, molecular weight and distributed mass spectrometric data of another polar compound in the sample to be detected; and (3) evaluating differences of the molecular compositions, molecular weights and distribution of the sample to be detected and the standard sample, detected in a wide band mode and a narrow band mode, by utilizing a spectral ratio method and a repeatability limit method to obtain an asphalt fingerprint identification result. Through the asphalt analysis discriminating method disclosed by the invention, the characteristics of the obtained asphalt fingerprint are remarkable and have very high representativeness and reliability; and the variety discrimination and product identification of petroleum asphalt, coal pitch, natural asphalt (consisting of rock asphalt and lake asphalt) can be realized by comparison of asphalt fingerprint mass spectrometric data of the standard sample and the sample to be detected.

A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (AIRLAB-MS) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a Fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol / methanol droplets containing 1 mM nicotine and is ˜50%. This transfer efficiency is significantly higher than values reported for similar techniques.

The invention relates to a method and a device for optimization of electric fields in measurement cells of Fourier transform ion cyclotron resonance mass spectrometers. The invention is based on the rationale that asymmetric electric fields with uniformly or non-uniformly perturbed field axes can appear in ion cyclotron resonance cells and therefore the axis of the magnetron orbit can become radially displaced. Shifted magnetron orbits negatively affect the cyclotron excitation, deteriorate the FT-ICR signal, increase the intensity of an even-numbered harmonics peak, lead to stronger side bands of the FT-ICR signal, and in extreme cases, cause loss of ions. The present invention helps in probing the shift of the magnetron motion, detecting parameters indicative of the offset of the electric field axis and / or correcting it by trimming it back to the geometric axis of the cell.

The present invention is a method and apparatus for generating a high frequency excitation signal for use in a mass spectrometer. Harmonics or aliases of a fundamental frequency contained in a signal from a digital-to-analog converter are used to excite ions in a Fourier transform ion cyclotron resonance mass spectrometer. The signal from the digital to analog converter may be filtered to remove the fundamental frequency or to remove unwanted harmonics or aliases.

Disclosed is apparatus and method for improving the signal by changing the voltage applied to an analyzing trap of a high resolving power Fourier Transform Ion Cyclotron Resonance (FT-ICR) mass spectrometer. More specifically, after the ion activation, a voltage different from that of a trap electrode is applied to an additional electrode in the center of the trap electrode, and the voltage is maintained until the end of a detection cycle. Applying the above method, the stability of the ions confined in a trap is more increased, and therefore, the detected time domain signal is being lengthened. The lengthened time domain signal results in an increase of the frequency or an improvement of the resolving power and the sensitivity of the mass-to-charge domain signal.

The invention relates to a method and a device for introducing ions into an ICR cell of Fourier transform ion cyclotron resonance mass spectrometers, in particular with a reduced the magnetron orbit. The invention is based on applying at least one gated DC voltage to a mantle electrode of the ICR cell prior to the excitation of the cyclotron motion such that injected ions are deflected inside the ICR cell in at least one radial direction.

A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (AIRLAB-MS) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a Fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol / methanol droplets containing 1 mM nicotine and is ˜50%. This transfer efficiency is significantly higher than values reported for similar techniques.

The invention discloses a nanoliter spray -FTICR-MS analysis method and device for organic matters dissolved in an environmental solid sample. The device comprises a nanoliter spray device and a Fourier transform ion cyclotron resonance mass spectrum, wherein the nano-liter spraying device comprises a glass spray head, a conductive needle, a switching rubber head, a duplex pressurizing ball and a gas storage bag, a sample solution loaded by the glass spray head is a mixed solution consisting of interstitial water and an organic solvent, and a nozzle is aligned with a sample inlet of the Fourier transform ion cyclotron resonance mass spectrum. The nano-liter spraying device and the FTICR-MS are combined for use, a sample is purified and enriched through solid-phase extraction, the ionization efficiency is improved and ion selectivity inhibition is reduced by changing the formula of a matrix and nano-liter spraying, direct analysis of interstitial water in an environmental solid sample can be realized, and the key problems that in the prior art, bioactive molecule signals need to be lost through solid-phase extraction pretreatment, and common electrospray source selective signal inhibition is needed are solved.

A method for tracing the migration direction of petroleum, comprising the following steps: 1) collecting at least two petroleum samples of homogeneous oil derived from the same source rock; 2) sample analysis, performing Fourier transform ion cyclotron resonance mass spectrometry analysis; 3 ) data processing, extract the carbon number, abundance and DBE structure information of N1S1 compounds, and obtain the abundance intensity of DBE=14, DBE=15, DBE=17 three types of N1S1 compounds; 4) determine the oil migration direction: according to DBE=14, DBE=15, DBE=17 Abundance intensity of the three types of N1S1 compounds, respectively calculate the abundance intensity percentages of the three types of compounds, and then analyze the abundance percentages of the three types of compounds, DBE=15 type N1S1 The direction in which the percentage of compound abundance increases is the direction of oil migration.

A system, method and computer program product are provided for calculating one or more indicative properties including one or more of the cetane number, octane number, pour point, cloud point and aniline point of oil fractions, from the density and Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) of a sample of an oil sample.

The invention can be summarized as follows. The present invention provides a method of displaying spectroscopic data comprising in steps of, i) obtaining spectroscopic data from a plurality of samples, each sample comprising one or more components wherein each component is characterized by an ordered pair (X,Y) of data comprising data element value X and data element value Y, wherein X is a data element value, equivalent or directly proportional to the mass of the component, and Y is a data element value equivalent or directly proportional to the amount of the component; ii) identifying all unique components comprising a common data element value X in said samples; computing the average of all X therefrom; and determining the average and optionally, the standard deviation for all Y values from all ordered data pairs comprising a common X; iii) generating a data structure comprising an array of codable cells, each cell assigned a color or other identifiable characteristic based on the relationship of the amount of each unique component present in each of said samples in relation to a predetermined value or other characteristic of the spectroscopic data. Also disclosed are data structures comprising spectroscopic data.

The invention relates to a method and a device for optimization of electric fields in measurement cells of Fourier transform ion cyclotron resonance mass spectrometers. The invention is based on the rationale that asymmetric electric fields with uniformly or non-uniformly perturbed field axes can appear in ion cyclotron resonance cells and therefore the axis of the magnetron orbit can become radially displaced. Shifted magnetron orbits negatively affect the cyclotron excitation, deteriorate the FT-ICR signal, increase the intensity of an even-numbered harmonics peak, lead to stronger side bands of the FT-ICR signal, and in extreme cases, cause loss of ions. The present invention helps in probing the shift of the magnetron motion, detecting parameters indicative of the offset of the electric field axis and / or correcting it by trimming it back to the geometric axis of the cell.

The present invention is a method and apparatus for generating a high frequency excitation signal for use in a mass spectrometer. Harmonics or aliases of a fundamental frequency contained in a signal from a digital-to-analog converter are used to excite ions in a Fourier transform ion cyclotron resonance mass spectrometer. The signal from the digital to analog converter may be filtered to remove the fundamental frequency or to remove unwanted harmonics or aliases.