2 results about "Hepatitis B virus core" patented technology

The present disclosure provides a photo-activated chemiluminescence detection kit and method for detecting hepatitis B virus core IgM type antibody. The detection kit comprises: reagent 1, luminescent microspheres coated with hepatitis B core antigen (HBcAg), which can react with singlet oxygen and generate a detectable light signal; reagent 2, anti-IgM antibody labeled with a first partner; and reagent 3, blocking reagent, which can reduce or eliminate interfering antibodies. The detection kit of the present disclosure destroys the structure of interfering antibodies by chemical and / or biological methods, thereby weakening or even eliminating the signal or shielded signal caused by interfering antibodies, which can significantly improve the accuracy of hepatitis B virus core IgM type antibody detection.

This invention provides a novel compound that can effectively prevent the proliferation of drug-resistant hepatitis B viruses. [Solution] A hydrophobic tag and morphothiazine, which is an allosteric modulator of the hepatitis B virus core protein, are linked by a linker. The ring-type carbocyclic is any of the following: adamantane ring, norbornene ring, norbornane ring, perhydroindene ring, decalin ring, perhydrofluorene ring, perhydroanthracene ring, perhydrophenanthrene ring, tricyclodecane ring, tricycloundecane ring, tetracyclododecane ring, perhydroacenaphthene ring, or perhydrophenalene ring. The novel compound according to the present invention can effectively suppress the proliferation of drug-resistant HBV.