The invention discloses Cr-containing steel for wire line core drilling and a manufacturing method thereof, and the manufacturing method is characterized by controlling the content of C, Si, Mn, Cr, Mo, V, Ti and Cu reasonably, using nitrogen in the steel effectively, depending on precipitation strengthening of V and Ti, adopting an appropriate deoxidization method, enhancing the toughness and guaranteeing the purity of the steel at the same time of refining grains, adopting the heat treatment process of tempering after rolling and utilizing bainite as the main structure, which enables the steel to have the performance of resisting cracks and delaying crackling. The yield strength of the steel is greater than 740MPa, the tensile strength is greater than 880MPa, the elongation rate is greater than 13 percent, the performance meets the use requirements of DZ75 steel grade, the steel has the production advantage of saving procedures and the cost advantage of saving energy, the mechanical property at room temperature is superior to that of steel that does not contain Cr, and the comprehensive properties of the product can compete with the comprehensive properties of imported products of the same steel grade, therefore, the product has good application prospect.