The invention provides Rupi hardness-softening paste according to the theory of traditional Chinese medicine and scientific practice about internal diseases treated with external therapy. The Rupi hardness-softening paste is prepared by mixing raw materials of Chinese medicaments and auxiliary materials, wherein the raw materials of Chinese medicaments (in part by weight) include: 5 to 100 of common burreed rhizome, 5 to 100 of zedoary, 5 to 100 of Gansui root, 5 to 100 of Szechuan lovage rhizome, 5 to 100 of euphorbia, 5 to 100 of raw arisaema root, 5 to 100 of rhubarb, 5 to 100 of common selfheal fruit-spike, 5 to 100 of mirabilite, 5 to 100 of gamboge, 5 to 100 of nardostachyos, 5 to 100 of Zhejiang fritillaria, 5 to 100 of pangolin scale, 5 to 100 of milkvetch, 5 to 100 of scorpion, 5 to 100 of white mustard seed, and 5 to 100 of Indian iphigenia bulb; and the auxiliary materials include Vaseline, propylene glycol, azone, wool grease and ethyl hydroxy benzoate. The Rupi hardness-softening paste of the invention has the effects of activating blood, regulating meridians, dispersing, rectifying the depressed liver-energy and softening hardness to dissipate stagnation, and has an obvious curing effect on simple hyperplasia of mammary glands. The Rupi hardness-softening paste has the advantages of convenient use, rapid onset, reinforced treating effect and no toxic nor side effect, and therefore is an ideal product for a patient suffering from simple hyperplasia of mammary glands.