The invention discloses a seaming mechanism of can manufacturing machinery. The seaming mechanism of the can manufacturing machinery comprises a guide piece, a plurality of rolling groups, a plurality of seaming shaft groups and a plurality of seaming mold groups, wherein the guide piece is arranged on a main shaft, provided with an annular guiding part and around the periphery of the main shaft; The rolling groups are located at the periphery of the main shaft in same space and are respectively provided with rolling shafts and rolling heads arranged axial end of the rolling shaft; the plurality of seaming shaft groups are adjacent to the corresponding rolling shafts, wherein each seaming shaft group is provided with a first seaming shaft, a second seaming shaft, a first guided part and a second guided part, and respectively bridged between the axial end of each seaming shaft and the guiding part; and the plurality of seaming mold groups are respectively adjacent to the corresponding rolling heads, each seaming mold group is provided with a column-shaped first seaming mold head and a column-shaped third seaming mold head, a first seaming arm part, a column-shaped second seaming mold head, wherein the first column-shaped first seaming mold head and the column-shaped third seaming mold head are in parallel to the first seaming shafts around the column shaft and are adjacently corresponding to the rolling heads, the first seaming arm part is bridged and fixedly connected among the other axial ends of the first seaming mold head, the third seaming mold head and the first sealing shaft, the column-shaped second seaming mold head is in parallel to the second seaming shaft around the column shaft and is adjacently corresponding to the rolling heads, and the second seaming arm part is bridged and fixedly connected between the other axial ends of the second seaming mold head and the second seaming shaft.