The invention discloses a characterization method of material fatigue, creep, and fatigue-creep interaction service life, and belongs to the field of service life prediction of aero-engine critical materials. The characterization method is used for solving service life characterization and prediction problems of materials under low cycle fatigue, creep, and fatigue-creep interaction conditions. According to the principles, a power function form service life prediction method non-linear behavior characterization capacity is established via fatigue-creep interaction, low cycle fatigue, and creeptests of materials at different holding time, and obtaining of effective holding time and normalization dimensionless service life via normalization calculation method. The characterization method iscapable of realizing accurate characterization of service life of materials under low cycle fatigue and fatigue-creep interaction conditions, and especially, consideration and accurate prediction ofcreep service life can be realized. The advantages of the characterization method are that consideration of both physical mechanisms and model implementation convenience is realized, and material lowcycle fatigue, creep, and fatigue-creep interaction service life characterization and prediction problems are solved effectively.