The invention discloses a self-centering pre-stressed concrete framework floor slab structure, which comprises spans with the quantity of N which are horizontally arranged, wherein each span comprises four main beams, secondary beams with the quantity of M, four framework columns and floor slabs, wherein the main beams are arranged between two adjacent framework columns through a pre-stressed steel stranded wire, each secondary beam is arranged between two opposite main beams, and the floor slab is arranged above the main beams and the secondary beams; every two adjacent spans share one main beam and two framework columns, in one of the spans, the secondary beams and the two main beams which are connected with the secondary beams are respectively and fixedly connected with the floor slab through a tightening device, and the rest two main beams are connected with the floor slab through a sliding device; and in each span of the rest spans, the main beams and the secondary beams are respectively connected with the floor slab through the sliding device. Under the action of single-direction earthquake, due to the adoption of the concrete framework floor slab structure, the damage to the self-centering pre-stressed concrete framework caused by the restriction effect of the floor slab can be reduced.