The invention discloses an antispasmodic medicine composition and a preparation method thereof, wherein the effective components of the traditional Chinese medicine composition comprises the following raw materials in daily dosage: 16-60g radix paeoniae alba, 10-60g liquorice and 10-30g pawpaw; and the preparation method comprises the following steps of: taking the radix paeoniae alba and the liquorice, adding water, stirring and soaking, decocting for 2-3 times in which each time is for 1-2 h, filtering, concentrating to an amount accounting for 1.2-1.5 times of the raw material medicine, cooling, adding 95% of alcohol until the alcohol content is 60-70%, stirring, standing, filtering, retrieving the alcohol from the filtrate, concentrating to a dense extract with a proportion of 1:(10-15), taking the pawpaw and crushing, soaking the pawpaw powder by 70% of alcohol accounting for 6-10 times of the weight of the pawpaw for 20-24 h, processing percolation so as to obtain percolation solution, and mixing the dense extract with the percolation solution so as to obtain the antispasmodic medicine composition; or taking the radix paeoniae alba, the pawpaw and the liquorice, crushing, adding water, stirring and soaking, decocting for 2-3 times in which each time is for 0.5-1 h, filtering so as to obtaining the filtrate, namely obtaining the antispasmodic medicine composition. The traditional Chinese medicine composition of the invention has accurate effects for treating muscle spasm, limbs pain, limitation of activity and hypermyotonia, has safe clinical application without side effect.