The invention discloses a large-stroke high-precision Z-axis worktable with a novel structure. The worktable comprises a base, a first support, a second support, a movable supporting rod, a worktable body and a precise movable positioning table. The first support and the second support are arranged on the base, the movable supporting rod is arranged on the first support in an upward and downward movable mode, the movable supporting rod is fixedly provided with a grating ruler extending vertically, the first support is provided with a grating reading head, the precise movable positioning table is arranged on the second support in an upward and downward movable mode, the lower end of the movable supporting rod is fixedly connected with the precise movable positioning table, and a drive device is arranged on the precise movable positioning table. Due to the fact that the center of the worktable body, the center of the grating ruler, the center of the grating reading head and the center of the precise movable positioning table are located on the same line, zero abbe errors of a system can be achieved theoretically, abbe errors of the system are reduced to the largest extent, and micro-nano measuring and micro-nano processing requirements can be met.