The invention discloses a method for preparing a
steroid drug intermediate by
coupling ozone produced by electrolyzing water with ozonation reaction in a microchannel reactor. According to the method, a double-membrane water-cooled
ozone generator is adopted, a beta-PbO2 catalyst is used as an
anode, a Pt / C material is used as a
cathode, and
gaseous ozone is generated under the condition of constant-current low-
voltage electrolyzed water. The generated
ozone gas reacts with an
alcohol solution of a
steroid drug precursor in a micro-channel reactor, and the
steroid drug intermediate is successfully prepared after purification. The beta-PbO2 catalyst used in the invention shows excellent performance and stability of electrolyzing water to produce ozone. The generated ozone reacts with an
alcohol solution of a steroid drug precursor, and the efficient gas-liquid
mass transfer performance of the microchannel reactor is combined, so that the
reaction rate is remarkably increased, and efficient preparation of a steroid drug intermediate is stably realized.