The invention relates to the technical field of vertical machining center equipment, and discloses an abrasion-preventing centrifugal protection device for a main shaft of a vertical machining center. The device comprises a first connecting shaft, a shaft key is fixedly connected to the outer side of the first connecting shaft, a first connecting block is clamped in the middle of the shaft key, a first connecting rod is fixedly connected to the outer side of the first connecting block, one end of the first connecting rod is fixedly connected with a first shell, and the bottom end of the first connecting shaft is rotationally connected with a second connecting block. According to the abrasion-preventing centrifugal protection device for the main shaft of the vertical machining center, through connection of the first connecting shaft and the second connecting block, the problem that a bearing in a main shaft in the prior art is prone to rusting is solved, centrifugal force is utilized, the flow speed of cooling liquid can be controlled, the cost is reduced, meanwhile, metal cuttings, dust and the like can be prevented from entering the main shaft, the purpose of prolonging the service life is achieved, the dead weight of the equipment is effectively reduced, and the reliability is greatly improved.