39 results about "Neoplasm/cancer" patented technology

Provided are compounds for targeted immunotherapy. The compounds are useful in the treatment of EGFR expressing tumors / cancers. Also provided are compositions comprising the compounds.

The invention relates to diagnostic, detection, screening and imaging methods. In various embodiments, methods of diagnosis, detection, screening and imaging include administering a cationic steroid antimicrobial or CSA to a subject having or at risk of having an infection or a hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in an amount effective to diagnose or detect the infection or the hyperproliferative disorder (e.g., a tumor, cancer or neoplasia) in the subject. In a particular aspect, a detectable CSA, namely CSA-13 labeled with 99mTc is used to detect the presence of an infection.

The invention discloses traditional Chinese medicine liquor for treating tumors and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine liquor mainly comprises more than 60 kinds of traditional Chinese medicines including cortex juglandis mandshuricae, fructus fici, livistona chinensis (Jacq.) R.Br., trapa natans L. (quadrangular), rabdosia rubescens, spreading hedyotis herb, rhizoma smilacis glabrae, barbed skullcap herb, Indian mockstrawberrg herb and the like, and is prepared by soaking the traditional Chinese medicines in pure-grain Baijiu (55-60% vol) according to a specific ratio, a specific sequence and specific time and then filtering. The traditional Chinese medicine liquor has the advantages that the traditional Chinese medicine liquor is used for treating various tumors (cancers) and applied to other metastatic cancer treatment and is capable of strengthening the body resistance, removing evils, softening hardness to dissipate stagnation, resisting cancers, detoxifying, reinforcing the vital essence, strengthening the primordial qi, activating blood circulation to remove stagnated blood, nourishing blood, achieving hemogenesis, invigorating the stomach, tonifying the spleen, clearing blood, cooling blood and clearing heat-fire; phagocytic ability of macrophagocytes can be improved, cancer cells can be killed directly or indirectly to promote lymphocyte transformation and induce interferon, canceration inducing factors are decreased, and accordingly cancer prevention, resistance to the cancers, cancer inhibition and cancer cell apoptosis are achieved; various cancers and forming thereof as well as a series of diseases caused by the various cancers can be prevented.

The invention relates to conjugates that bind to Her2 / neu, methods of using conjugates that bind to Her2 / neu and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express Her2 / neu.

The invention relates to conjugates that bind to targets, methods of using conjugates that bind to targets and methods of treating undesirable or aberrant cell proliferation or hyperproliferative disorders, such as tumors, cancers, neoplasia and malignancies that express a target.

This invention relates to the field of therapeutic RNAs for treatment of solid tumor cancers.

Evofosfamide (TH-302) or an analog thereof has a specific inhibitory effect on a cell having a specific gene mutation, in particular on a DNA repair-damaged cell. The cell or tissue has at least one or more gene mutations in BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2,XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP, and ERCC5. For this, a medical use of evofosfamide (TH-302) or an analog thereof in treating tumors or cancer in a cancer patient having the specific gene mutation(s) is provided.

The invention discloses an anti-tumor traditional Chinese medicine composition and a preparation method thereof. The anti-tumor traditional Chinese medicine composition comprises the following raw materials in parts by weight: 12-27 parts of ramulus cinnamomi, 3-12 parts of pseudobulbus cremastrae seu pleiones, 15-45 parts of poria cocos, 10-50 parts of liquorice roots, 10-40 parts of seaweeds, 10-40 parts of radix scrophulariae, 10-40 parts of radix ranunculi ternati, 10-45 parts of concha ostreae, 10-30 parts of rhizoma sparganii, 5-15 parts of radix aucklandiae, 5-15 parts of bulbus fritillariae cirrhosae and 5-30 parts of raw rhizoma pinelliae. The traditional Chinese medicine composition further comprises the following raw materials in parts by weight: 60 parts of spica prunellae and 75 parts of herba hedyotidis diffusae. The traditional Chinese medicine composition further comprises a medicinal guide. Dialectical treatment is carried out according to the difference of affected parts of patients and the difference of clinical main symptoms, and the medicinal guide is added on the basis of an original formula. The traditional Chinese medicines are made into traditional Chinese medicine pills, because the traditional Chinese medicine pills are convenient to take, and the dosage is easy to master; anti-tumor and anti-cancer common medicines can be prepared into main medicine pills, and then different medicinal guide pills are matched according to the different tumor and cancer affected parts so as to avoid the trouble of the re-matching for the different tumor and cancer affected parts each time, such that the medicine preparation efficiency is improved; and the medicine has high-efficiency anti-tumor activity, no obvious toxic or side effect and very low drug resistance.

The present disclosure provides a data processing system and electronic equipment for acquiring the position and contour of a tumor in a CT image, acquiring a CT image, and performing image segmentation on the acquired CT image by using a particle swarm optimization algorithm to obtain a segmented CT image data matrix; Establish a QSOFM classifier model, use the segmented CT image data matrix for model training; use the QSOFM classifier model to identify the cancerous tumor types in the CT image, and obtain the location and contour of the cancerous tumor in the CT image based on the multi-connected region segmentation method Information; this disclosure makes image segmentation more detailed and reduces redundant data, which makes the automatic puncture device have a higher recognition rate of tumors in CT images, and locates the tumor position more quickly and accurately, and improves the automation of the automatic puncture device. Computer-assisted therapy lays the groundwork.

Glufosfamide or analogues thereof have specific inhibitory effects on cells with specific gene variations, specifically, DNA repairs damaged cells, the cells or tissues at least have one or more genemutations of BRCA1, BRCA2, FANCD1, FANCD2, ATM, ATR, CHEK1, CHEK2, CTP, BARD1, BRIP1, PALB2, RAD51D, RAD51C, RAD52, RAD54, RAD55, RAD57, FAM175, NBN, Rad50, MER11, p53, NBS1, XRS2, XRCC2, XRCC3, ERCC1, ERCC2, ERCC3, ERCC4, XRCC1, Ku80, MHS6, MGMT, PARP or ERCC5. The analogues are esters obtained by esterification reaction of one or more hydroxyl groups in glufosfamide molecules with organic acid and inorganic oxyacid; esters obtained by esterification reaction of one or more hydroxyl groups in glufosfamide molecules with amino acid; and salts obtained by reaction of glufosfamide molecules withan acid. Therefore, provided is medical uses of glufosfamide or the analogues thereof in treatment of tumors and cancer diseases of cancer patients with specific gene variations.

Described herein are doppel-targeting molecules (e.g., antibodies) useful for inhibiting pathological angiogenesis and treating diseases and conditions associated with pathological angiogenesis, such as tumors, cancers, atherosclerosis, tuberculosis, asthma, pulmonary arterial hypertension (PAH), neoplasms and neoplasm-related conditions, and for detecting doppel expression in a subject. Related compositions and methods also are described.

The invention relates to transfer equipment, and especially relates to a transfer deck chair for tumor cancer chemotherapy. The chair comprises a turnover type supporting mechanism and a movable base arranged at the bottom of the turnover type supporting mechanism, and universal wheels for driving the movable base to move are arranged at the four corners of the bottom of the movable base. An upper hip supporting plate, a lower hip supporting plate and a hip supporting plate are kept horizontal, so that when a transfer person lies flat and needs to sit down, the upper hip supporting plate is made to stand upwards, the lower hip supporting plate is made to fall down, and the part above the hip and the part below the hip of the transfer person are supported; in addition, the upper hip supporting plate and the lower hip supporting plate are fixed through the overturning piece, so that the adjustment range of the overturning angle of the upper hip supporting plate and the lower hip supporting plate is widened.

The invention relates to a traditional Chinese medicine, in particular to a medicine which is used for treating malignant tumors and has prevention and treatment functions, and solves the problem that the modern medical circle depends on Western medicine means to treat cancers but with insignificant effect and obvious side effect. The traditional Chinese medicine consists of astragalus root, Codonopsis pilosula, honeysuckle, dandelion, bupleurum falcatum L., baikal skullcap root, radix paeoniae alba, Irkutsk anemone Rhizome, rhizoma sparganii, arisaema consanguineum schott, pinellia tuberifera, Oldenlandia diffusa, notoginseng, radix sophorae subprostratae, and radices curcumae zedoariae. The traditional Chinese medicine has the functions of prohibiting the proliferation of various cancercells and killing various cancer cells; and has obvious treatment effects to various tumors and cancers.

The invention discloses pills for treating the bone cancer and an application thereof. The pills are composed of the following components: 50 g of mercury, 50 g of potassium nitrate, 50 g of alum, 20g of verdigris, 15 g of chalcanthite, 25 g of yellow lead, 50 g of melanterite, 50 g of halite, 2.5 g of musk and 2.5 g of borneol. According to the pills for treating the bone cancer and the application thereof, the pills are mainly used for treating gangrene of finger or toe (angiitis), suppurative osteomyelitis (bone tuberculosis and osteomyelitis), venereal syphilis, rheumatic arthritis, rheumatoid arthritis, malignant tumor (carcinoma) and osteosarcoma (bone cancer), and have a good treatment effect.