The invention discloses an oxazole thiadiazole organic copper compound, its preparation method, preparation and application in controlling agricultural plant diseases. The preparation method comprises the following steps: adding 3-hydroxy-5-methyl isoxazole (hymexazol) and 2-amino-5-mercapto-1,3,4-thiadiazole and cupric salts in an organic solvent, reacting for 0.5-2 h, after the reaction successively carrying out separation, washing and drying to obtain the novel oxazole thiadiazole organic copper compound, that is, Cu-3-hydroxy-5-methyl isoxazole-2-amino-5-mercapto-1,3,4-thiadiazole. The obtained compound has stable properties and wide fungicide spectrum, can be made into wettable powder, dry suspending agents and aqueous suspending agents and the like, has outstanding control effects on main diseases of various crops, especially can control the diseases caused by Fusarium, aphanomyces invadans, Pythium aphanidermatum, and Corticium, and has special efficacy on various soil borne diseases and seedling damping off.