The invention relates to a diagonal flow pump impeller hydraulic design method. A design formula about main geometric parameters of the impeller is given, and includes an included angle Alpha between the outlet of the diagonal flow pump impeller and the horizontal line, the actual thickness Delta of each point of each vane, vane wrap angle Phi, the inlet fillet radius RTS of the rear cover plate of the impeller, the number z of impeller vanes, the diameter D2 of the impeller outlet, the width b2 of the vane outlet, the equivalent diameter D0 of the impeller inlet, a distance ZE between the vane inlet of the front cover plate and the outlet of the front cover plate of the impeller, a distance g1 from the inlet edge to the initial end of the curve of the front cover plate, the inlet fillet radius RDB of the front cover plate of the impeller, round nut radius Ra of the impeller, round nut height Rb of the impeller, the placing angle of the vane Beta, the placing angles Beta1 of inlet of the vane, the placing angles Beta2 of inlet of the vane, the slipping coefficient Rho and the hydraulic efficiency Etah. According to the impeller of the diagonal flow pump designed by the invention, the hydraulic efficiency of the impeller and the stability performance of the diagonal flow pump are improved, and computer programming is facilitated, and thereby the original similar design method and the velocity coefficient method of the diagonal flow pump can be replaced to a great extent.