The invention discloses a construction method of an uplift pressure resisting concrete protection slab. The construction method comprises the following construction steps of a, construction measuringlofting, b, base cleaning, c, foundation tamping and cushion layer replacing, d, cushion layer face protection, e, prefabricated concrete protection slab paving and splicing, f, pile screwing, and g,surface and joint water stopping. By means of the construction method of the uplift pressure resisting concrete protection slab, the function of uplift pressure resistance of the concrete protection slab can be effectively improved, the conditions that the concrete protection slab is cracked, fractured and the like due to the insufficient protection slab strength, wave impact, cushion layer blockstone movement, soil sedimentation and the like are effectively prevented, and the service life of the concrete protection slab is prolonged.