The present invention comprises an optical apparatus, methods and uses for real-time (video-rate) 
multimodal imaging, for example, contemporaneous measurement of 
white light reflectance, 
native tissue autofluorescence and near 
infrared images with an 
endoscope. These principles may be applied to various optical apparati such as microscopes, endoscopes, telescopes, cameras etc. to view or analyze the interaction of light with objects such as planets, plants, rocks, animals, cells, tissue, proteins, 
DNA, semiconductors, etc. Multi-band spectral images may provide morphological data such as 
surface structure of 
lung tissue whereas chemical make-up, sub-structure and other object characteristics may be deduced from spectral signals related to reflectance or light radiated (emitted) from the object such as 
luminescence or 
fluorescence, indicating endogenous chemicals or exogenous substances such as dyes employed to enhance 
visualization, drugs, therapeutics or other agents. Accordingly, one embodiment of the present invention discusses simultaneous 
white light reflectance and 
fluorescence imaging. Another embodiment describes the addition of another reflectance imaging modality (in the near-IR spectrum). Input (illumination) spectrum, optical modulation, 
optical processing, object interaction, output spectrum, 
detector configurations, synchronization, 
image processing and display are discussed for various applications.