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This application provides an application of a Raman spectroscopy biomarker combination in the preparation of diagnostic products for diabetic foot osteomyelitis, belonging to the field of biomedical detection technology. The biomarker combination includes a first type of characteristic spectrum showing a significant increase in intensity or intensity ratio in positive samples of diabetic foot osteomyelitis compared to negative samples, and a second type of characteristic spectrum showing a significant decrease in intensity; specifically involving 1070 cm⁻¹. ‑1 With 1450 cm ‑1 The strength ratio, (851+873+917) cm ‑1 Region and 1656 cm ‑1 The strength ratio, and 960 cm ‑1 1001 cm ‑1 1103 cm ‑1 1450 cm ‑1 1590 cm ‑1 1656 cm ‑1 The intensity of multiple characteristic wavelengths was measured. The diagnostic model constructed based on this combination demonstrated good discrimination performance in testing. The method provided in this application has the advantages of being rapid and low-cost, offering a new solution for the early screening and auxiliary diagnosis of diabetic foot osteomyelitis.