The invention discloses a biodiesel distillation vacuum tail gas treatment device, which is characterized in that the inlet of a tail gas vacuum unit is connected with a vacuum outlet of a distillation tower, the outlet of the tail gas vacuum unit is connected with the working fluid tank of the tail gas vacuum unit, the outlet of the tank is connected with a horizontal condenser, the horizontal condenser is provided with a tail gas outlet, a sewage outlet and a cooling water inlet and outlet, the tail gas outlet is connected with the inlet of a methanol receiving tank, the outlet of the receiving tank is connected with a methanol separator, the lower portion of the receiving tank is provided with a liquid methanol outlet and connected with a methanol separation outlet pump, a tail gas outlet is formed in the top of the methanol separator, a heat mixing pipe steam inlet pipe is arranged on the tail gas outlet, an oxygen content control system is arranged beside the tail gas outlet, the tail gas outlet is sequentially connected with a heat mixing pipe and a vacuum tail gas pipe, a pipeline separator, a pressure control system, a gravel flame arrester, a fire extinguishing steam pipe, a front temperature control system, a safety water seal, a stainless steel flame arrester and a rear temperature control system are sequentially installed on the vacuum tail gas pipe, and then the vacuum tail gas pipe is connected into a combustion furnace. The biodiesel distillation vacuum tail gas treatment device is safe to operate, environment-friendly, efficient and low in production cost.