The invention discloses an ultrasonic wave airtightness detecting system based on multiple sensors and a method thereof. The system comprises a plurality of ultrasonic wave transmitters which are arranged in a container, an energy transducer set, a signal conditioning circuit, a main processor and a signal output module, wherein the energy transducer set, the signal conditioning circuit, the main processor and the signal output module are successively connected. The main processor is used for converting an amplified and filtered ultrasonic wave to a digital signal, and processes the digital signal through a fuzzy identification algorithm, a weak leakage determining algorithm and a data fusion and leakage determining algorithm, thereby obtaining a consistency interpretation to the leakage condition after fusing the signals of the sensors, converting a determining result to an analog signal, and transmitting the analog signal to an information terminal for displaying. The ultrasonic wave airtightness detecting system and the method thereof have high detecting precision and high detecting capability for weak leakage signals. Furthermore the ultrasonic wave airtightness detecting system has advantages of small size, high convenience in carrying, high sensitivity, high stability, and high benefit for dynamic online detection.