The invention discloses a skin anastomat convenient to use at multiple angles, which comprises a skin anastomat body, a first hydraulic cylinder, a medicine spraying assembly, a second manipulator, an adjusting assembly, an illuminating lamp and a control box, and is characterized in that the skin anastomat body is provided with a first slide way, the first slide way is slidably connected with a first sliding block, meanwhile, a first electric telescopic rod is fixed to the first sliding block, a threaded fixing piece is fixed to one end of the first electric telescopic rod, the medicine spraying assembly is used for sterilizing and cleaning a wound, a first fixing plate is fixed to the second manipulator, and the adjusting assembly is used for closing up the wound. According to the skin anastomat convenient to use at multiple angles, an operation wound can be directly folded, the angle of a folding plate can be adjusted according to needs, disinfection and cleaning can be carried out before suture and during operation suture, the spray head and the disinfection gauze can rotate at multiple angles, and light supplementing treatment can be carried out when light is insufficient.