The invention discloses a shock insulation groove system of a novel house building foundation shock insulation structure. The shock insulation groove system comprises a leakage-proof shock insulation groove formed between a shock insulation building body and a peripheral fixture, a shock insulation groove retaining wall, an underground outer wall, a reinforced concrete cushion layer at the bottom of the shock insulation groove, and a one-way compression laminated polystyrene foam filling body stuffed in the shock insulation groove, wherein the shock insulation groove retaining wall and the underground outer wall are arranged in the shock insulation groove. The shock insulation groove system has very high horizontal compression performance and necessary vertical strength and rigidity, so that the seismic isolation groove system can freely move in the horizontal direction under the action of an earthquake and can vertically meet the requirement for passing of personnel. The shock insulation groove system has the advantages that the industrialization degree is high, mounting and construction are easy, misoperation of constructors is reduced, the construction speed is increased, it is guaranteed that the upper structure of the shock insulation building body and a peripheral site fixture 2 can freely deform, and the shock insulation efficiency of the shock insulation structure is improved.